The PI3K-AKT pathway: A plausible therapeutic target in Parkinson's disease

IF 2.8 4区医学 Q2 PATHOLOGY Experimental and molecular pathology Pub Date : 2023-02-01 DOI:10.1016/j.yexmp.2022.104846

Ahsas Goyal (Assistant Professor), Anant Agrawal, Aanchal Verma, Nandini Dubey

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引用次数: 6

Abstract

Parkinson's disease is a common progressive and multifactorial neurodegenerative disease, characterized by the loss of midbrain dopaminergic neurons. Numerous pathological processes including, inflammation, oxidative stress, mitochondrial dysfunction, neurotransmitter imbalance, and apoptosis as well as genetic factors may lead to neuronal degeneration. With the emergence of aging population, the health problem and economic burden caused by PD also increase. Phosphatidylinositol 3-kinases-protein kinase B (PI3K-AKT) signaling pathway regulates signal transduction and biological processes such as cell proliferation, apoptosis and metabolism. According to reports, it regulates neurotoxicity and mediates the survival of neurons. Accumulating evidences indicate that some natural products can play a neuroprotective role by activating PI3K-AKT pathway, providing an effective resource for the discovery of potential therapeutic drugs. The current review provides an overview of the PI3K-AKT signaling pathway and review the relationship between this signaling pathway and PD.

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PI3K-AKT通路:帕金森病可能的治疗靶点

帕金森病是一种常见的进行性多因素神经退行性疾病，其特征是中脑多巴胺能神经元的丧失。许多病理过程，包括炎症、氧化应激、线粒体功能障碍、神经递质失衡、细胞凋亡以及遗传因素，都可能导致神经元变性。随着人口老龄化的出现，帕金森病引起的健康问题和经济负担也在增加。磷脂酰肌醇3-激酶-蛋白激酶B（PI3K-AKT）信号通路调节信号转导和细胞增殖、凋亡和代谢等生物学过程。据报道，它调节神经毒性并介导神经元的存活。越来越多的证据表明，一些天然产物可以通过激活PI3K-AKT通路发挥神经保护作用，为发现潜在的治疗药物提供了有效的资源。目前的综述提供了PI3K-AKT信号通路的概述，并综述了该信号通路与PD之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental and molecular pathology 医学-病理学

CiteScore

8.90

自引率

0.00%

发文量

审稿时长

11.5 weeks

期刊介绍： Under new editorial leadership, Experimental and Molecular Pathology presents original articles on disease processes in relation to structural and biochemical alterations in mammalian tissues and fluids and on the application of newer techniques of molecular biology to problems of pathology in humans and other animals. The journal also publishes selected interpretive synthesis reviews by bench level investigators working at the "cutting edge" of contemporary research in pathology. In addition, special thematic issues present original research reports that unravel some of Nature''s most jealously guarded secrets on the pathologic basis of disease. Research Areas include: Stem cells; Neoangiogenesis; Molecular diagnostics; Polymerase chain reaction; In situ hybridization; DNA sequencing; Cell receptors; Carcinogenesis; Pathobiology of neoplasia; Complex infectious diseases; Transplantation; Cytokines; Flow cytomeric analysis; Inflammation; Cellular injury; Immunology and hypersensitivity; Athersclerosis.