Targeting DEAD-box RNA helicases: The emergence of molecular staples.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-03-01 DOI:10.1002/wrna.1738
Sai Kiran Naineni, Francis Robert, Bhushan Nagar, Jerry Pelletier
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引用次数: 6

Abstract

RNA helicases constitute a large family of proteins that play critical roles in mediating RNA function. They have been implicated in all facets of gene expression pathways involving RNA, from transcription to processing, transport and translation, and storage and decay. There is significant interest in developing small molecule inhibitors to RNA helicases as some family members have been documented to be dysregulated in neurological and neurodevelopment disorders, as well as in cancers. Although different functional properties of RNA helicases offer multiple opportunities for small molecule development, molecular staples have recently come to the forefront. These bifunctional molecules interact with both protein and RNA components to lock them together, thereby imparting novel gain-of-function properties to their targets. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Small Molecule-RNA Interactions RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications.

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靶向DEAD-box RNA解旋酶:分子钉的出现。
RNA解旋酶是一个在介导RNA功能中起关键作用的蛋白大家族。从转录到加工、转运和翻译、储存和衰变,它们都涉及到涉及RNA的基因表达途径的各个方面。由于一些家族成员在神经和神经发育障碍以及癌症中存在失调,因此对开发RNA解旋酶的小分子抑制剂有很大的兴趣。尽管RNA解旋酶的不同功能特性为小分子的发展提供了多种机会,但分子主食近年来已成为研究的前沿。这些双功能分子与蛋白质和RNA组分相互作用,将它们锁在一起,从而赋予它们的靶标新的功能获得特性。本文分类如下:RNA与蛋白质和其他分子的相互作用>小分子-RNA相互作用> RNA与蛋白质和其他分子的相互作用>蛋白质-RNA相互作用:功能意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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