Maria-Alexandra Papadimitriou, Konstantina Panoutsopoulou, Katerina-Marina Pilala, Andreas Scorilas, Margaritis Avgeris
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引用次数: 4
Abstract
Methylation of the fundamental macromolecules, DNA/RNA, and proteins, is remarkably abundant, evolutionarily conserved, and functionally significant in cellular homeostasis and normal tissue/organism development. Disrupted methylation imprinting is strongly linked to loss of the physiological equilibrium and numerous human pathologies, and most importantly to carcinogenesis, tumor heterogeneity, and cancer progression. Mounting recent evidence has documented the active implication of miRNAs in the orchestration of the multicomponent cellular methylation machineries and the deregulation of methylation profile in the epigenetic, epitranscriptomic, and epiproteomic levels during cancer onset and progression. The elucidation of such regulatory networks between the miRNome and the cellular methylation machineries has led to the emergence of a novel subclass of miRNAs, namely "epi-miRNAs" or "epi-miRs." Herein, we have summarized the existing knowledge on the functional role of epi-miRs in the methylation dynamic landscape of human cancers and their clinical utility in modern cancer diagnostics and tailored therapeutics. This article is categorized under: RNA in Disease and Development > RNA in Disease.
基本大分子,DNA/RNA和蛋白质的甲基化是非常丰富的,进化上保守的,在细胞稳态和正常组织/生物体发育中具有重要的功能。甲基化印迹的破坏与生理平衡的丧失和许多人类病理密切相关,最重要的是与致癌、肿瘤异质性和癌症进展有关。最近越来越多的证据表明,在癌症发生和发展过程中,mirna在多组分细胞甲基化机制的协调和表观遗传、表转录组学和表观蛋白质组学水平的甲基化谱的解除中具有积极意义。miRNome和细胞甲基化机制之间的这种调控网络的阐明导致了一种新的mirna亚类的出现,即“epi- mirna”或“epi-miRs”。在此,我们总结了epi-miRs在人类癌症甲基化动态图景中的功能作用及其在现代癌症诊断和定制治疗中的临床应用的现有知识。本文分类为:RNA in Disease and Development > RNA in Disease。
期刊介绍:
WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.