Tumor lactic acid: a potential target for cancer therapy

IF 6.9 3区 医学 Q1 CHEMISTRY, MEDICINAL Archives of Pharmacal Research Pub Date : 2023-02-02 DOI:10.1007/s12272-023-01431-8
Jun-Kyu Byun
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引用次数: 2

Abstract

Tumor development is influenced by circulating metabolites and most tumors are exposed to substantially elevated levels of lactic acid and low levels of nutrients, such as glucose and glutamine. Tumor-derived lactic acid, the major circulating carbon metabolite, regulates energy metabolism and cancer cell signaling pathways, while also acting as an energy source and signaling molecule. Recent studies have yielded new insights into the pro-tumorigenic action of lactic acid and its metabolism. These insights suggest an anti-tumor therapeutic strategy targeting the oncometabolite lactic acid, with the aim of improving the efficacy and clinical safety of tumor metabolism inhibitors. This review describes the current understanding of the multifunctional roles of tumor lactic acid, as well as therapeutic approaches targeting lactic acid metabolism, including lactate dehydrogenase and monocarboxylate transporters, for anti-cancer therapy.

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肿瘤乳酸:癌症治疗的潜在靶点
肿瘤的发展受到循环代谢产物的影响,大多数肿瘤都暴露在显著升高的乳酸水平和低水平的营养物质中,如葡萄糖和谷氨酰胺。肿瘤源性乳酸是主要的循环碳代谢产物,它调节能量代谢和癌症细胞信号通路,同时也是能量来源和信号分子。最近的研究对乳酸的促肿瘤作用及其代谢产生了新的见解。这些见解提出了一种靶向肿瘤代谢产物乳酸的抗肿瘤治疗策略,旨在提高肿瘤代谢抑制剂的疗效和临床安全性。这篇综述描述了目前对肿瘤乳酸多功能作用的理解,以及针对乳酸代谢的治疗方法,包括乳酸脱氢酶和单羧酸转运蛋白,用于抗癌治疗。
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来源期刊
CiteScore
13.40
自引率
9.00%
发文量
48
审稿时长
3.3 months
期刊介绍: Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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