In silico modeling for the hepatic circulation and transport: From the liver organ to lobules.

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL WIREs Mechanisms of Disease Pub Date : 2023-03-01 DOI:10.1002/wsbm.1586
Harvey Ho, Shawn Means, Soroush Safaei, Peter John Hunter
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引用次数: 1

Abstract

The function of the liver depends critically on its blood supply. Numerous in silico models have been developed to study various aspects of the hepatic circulation, including not only the macro-hemodynamics at the organ level, but also the microcirculation at the lobular level. In addition, computational models of blood flow and bile flow have been used to study the transport, metabolism, and clearance of drugs in pharmacokinetic studies. These in silico models aim to provide insights into the liver organ function under both healthy and diseased states, and to assist quantitative analysis for surgical planning and postsurgery treatment. The purpose of this review is to provide an update on state-of-the-art in silico models of the hepatic circulation and transport processes. We introduce the numerical methods and the physiological background of these models. We also discuss multiscale frameworks that have been proposed for the liver, and their linkage with the large context of systems biology, systems pharmacology, and the Physiome project. This article is categorized under: Metabolic Diseases > Computational Models Metabolic Diseases > Biomedical Engineering Cardiovascular Diseases > Computational Models.

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肝脏循环和运输的计算机模拟:从肝器官到小叶。
肝脏的功能主要取决于它的血液供应。许多计算机模型已经被开发出来,用于研究肝循环的各个方面,不仅包括器官水平的宏观血流动力学,还包括小叶水平的微循环。此外,在药代动力学研究中,血流和胆汁流量的计算模型已被用于研究药物的转运、代谢和清除。这些计算机模型旨在深入了解健康和患病状态下的肝脏器官功能,并协助定量分析手术计划和术后治疗。本综述的目的是提供最新的最先进的肝脏循环和运输过程的计算机模型。我们介绍了这些模型的数值方法和生理背景。我们还讨论了为肝脏提出的多尺度框架,以及它们与系统生物学、系统药理学和生理组项目的大背景的联系。本文分类如下:代谢疾病>计算模型代谢疾病>生物医学工程心血管疾病>计算模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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