Organoids of the male reproductive system: Challenges, opportunities, and their potential use in fertility research.

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL WIREs Mechanisms of Disease Pub Date : 2023-03-01 DOI:10.1002/wsbm.1590
Daniela Patrício, Joana Santiago, João F Mano, Margarida Fardilha
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引用次数: 5

Abstract

Organoids are units of function of a given organ able to reproduce, in culture, a biological structure similar in architecture and function to its counterpart in vivo. Today, it is possible to develop an organoid from a fragment of tissue, a stem cell located in an adult organ, an embryonic stem cell, or an induced pluripotent stem cell. In the past decade, many organoids have been developed which mimic stomach, pancreas, liver and brain tissues, optic cups, among many others. Additionally, different male reproductive system organs have already been developed as organoids, including the prostate and testis. These 3D cultures may be of great importance for urological cancer research and have the potential to be used in fertility research for the study of spermatozoa production and maturation, germ cells-somatic cells interactions, and mechanisms of disease. They also provide an accurate preclinical pipeline for drug testing and discovery, as well as for the study of drug resistance. In this work, we revise the current knowledge on organoid technology and its use in healthcare and research, describe the male reproductive system organoids and other biomaterials already developed, and discuss their current application. Finally, we highlight the research gaps, challenges, and opportunities in the field and propose strategies to improve the use of organoids for the study of male infertility situations. This article is categorized under: Reproductive System Diseases > Stem Cells and Development Reproductive System Diseases > Biomedical Engineering.

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男性生殖系统类器官:挑战、机遇及其在生育研究中的潜在应用。
类器官是特定器官的功能单位,能够在培养中复制与其体内对应器官在结构和功能上相似的生物结构。如今,从组织碎片、成人器官中的干细胞、胚胎干细胞或诱导多能干细胞中培育出类器官是可能的。在过去的十年里,许多类器官已经被开发出来,它们模仿了胃、胰腺、肝脏和脑组织、视杯等许多其他组织。此外,不同的男性生殖系统器官已经发展成为类器官,包括前列腺和睾丸。这些3D培养物可能对泌尿系统癌症的研究具有重要意义,并有可能用于生殖研究,研究精子的产生和成熟、生殖细胞-体细胞的相互作用以及疾病的机制。它们还为药物测试和发现以及耐药性研究提供了准确的临床前管道。在这项工作中,我们修订了目前关于类器官技术及其在医疗保健和研究中的应用的知识,描述了已经开发的男性生殖系统类器官和其他生物材料,并讨论了它们目前的应用。最后,我们强调了该领域的研究差距、挑战和机遇,并提出了改善类器官在男性不育症研究中的应用的策略。本文分类如下:生殖系统疾病>干细胞与发育生殖系统疾病>生物医学工程。
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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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