The Wound Healing Potential of Lignosus rhinocerus and Other Ethno-myco Wound Healing Agents.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.1080/12298093.2022.2164641

Hui-Yeng Y Yap, Mohammad Farhan Ariffeen Rosli, Soon-Hao Tan, Boon-Hong Kong, Shin-Yee Fung

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引用次数: 2

Abstract

Wound care has become increasingly important over the years. Various synthetic products for wound care treatment have been reported to cause toxic side effects and therefore natural products are in significant demand as they have minimal side effects. The presence of bioactive compounds in medicinal mushrooms contributes to various biological activities which assist in the early inflammatory phase, keratinocyte proliferation, and its migration enhancement which are pertinent to wound rehabilitation. Lignosus rhinocerus (tiger milk mushroom) can reduce the inflammation phase in wound healing by fighting off bacterial infection and modulating pro-inflammatory cytokines expression in the early stage to avoid prolonged inflammation and tissue damage. The antibacterial, immunomodulating, and anti-inflammatory activities exhibited by most macrofungi play a key role in enhancing wound healing. Several antibacterial and antifungal compounds sourced from traditional botanicals/products may prevent further complications and reoccurrence of injury to a wounded site. Scientific studies are actively underway to ascertain the potential use of macrofungi as a wound healing agent.

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犀牛木与其他民族麦可伤口愈合剂的伤口愈合潜力。

多年来，伤口护理变得越来越重要。据报道，用于伤口护理治疗的各种合成产品会引起毒副作用，因此天然产品的需求量很大，因为它们的副作用最小。药用蘑菇中生物活性化合物的存在有助于各种生物活性，这些活性有助于早期炎症阶段，角质细胞增殖及其迁移增强，这与伤口康复有关。老虎乳菇可以通过抵抗细菌感染和调节促炎细胞因子的早期表达来减少伤口愈合中的炎症阶段，从而避免长期的炎症和组织损伤。大多数大型真菌所表现出的抗菌、免疫调节和抗炎活性在促进伤口愈合中起着关键作用。从传统植物药/产品中提取的几种抗菌和抗真菌化合物可以防止进一步的并发症和受伤部位损伤的再次发生。科学研究正在积极进行，以确定大型真菌作为伤口愈合剂的潜在用途。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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