Phytochemistry and pharmacology of natural prenylated flavonoids

IF 6.9 3区 医学 Q1 CHEMISTRY, MEDICINAL Archives of Pharmacal Research Pub Date : 2023-04-14 DOI:10.1007/s12272-023-01443-4
Hua-Wei Lv, Qiao-Liang Wang, Meng Luo, Meng-Di Zhu, Hui-Min Liang, Wen-Jing Li, Hai Cai, Zhong-Bo Zhou, Hong Wang, Sheng-Qiang Tong, Xing-Nuo Li
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引用次数: 5

Abstract

Prenylated flavonoids are a special kind of flavonoid derivative possessing one or more prenyl groups in the parent nucleus of the flavonoid. The presence of the prenyl side chain enriched the structural diversity of flavonoids and increased their bioactivity and bioavailability. Prenylated flavonoids show a wide range of biological activities, such as anti-cancer, anti-inflammatory, neuroprotective, anti-diabetic, anti-obesity, cardioprotective effects, and anti-osteoclastogenic activities. In recent years, many compounds with significant activity have been discovered with the continuous excavation of the medicinal value of prenylated flavonoids, and have attracted the extensive attention of pharmacologists. This review summarizes recent progress on research into natural active prenylated flavonoids to promote new discoveries of their medicinal value.

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天然烯丙基黄酮的植物化学和药理学研究
烯丙基化类黄酮是一类特殊的类黄酮衍生物,在类黄酮的母核中含有一个或多个烯丙基。烯丙基侧链的存在丰富了黄酮类化合物的结构多样性,提高了其生物活性和生物利用度。烯丙基黄酮类化合物具有广泛的生物活性,如抗癌、抗炎、神经保护、抗糖尿病、抗肥胖、心脏保护和抗破骨细胞活性等。近年来,随着对烯酰化类黄酮药用价值的不断挖掘,发现了许多具有显著活性的化合物,引起了药理学家的广泛关注。本文综述了近年来天然活性戊烯酸类黄酮的研究进展,以期促进其药用价值的新发现。
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来源期刊
CiteScore
13.40
自引率
9.00%
发文量
48
审稿时长
3.3 months
期刊介绍: Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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