Management of patients with statin intolerance

IF 6.1 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Best practice & research. Clinical endocrinology & metabolism Pub Date : 2023-05-01 DOI:10.1016/j.beem.2022.101714
Alexandra Nicole Martirossian MD (Endocrinology Fellow), Anne Carol Goldberg MD (Professor of Medicine)
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引用次数: 5

Abstract

Atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality, and statins have become a cornerstone in its treatment and prevention. Despite the well-documented benefits of statins, many patients stop taking them, with adverse muscle symptoms being a commonly cited reason. Although some statin-associated adverse muscle effects are real, some can be attributed to the nocebo effect, which is the patient's perception of harm. The purpose of this article is to review the literature on statin safety, particularly that related to muscle, to analyze adverse effects, and to propose various treatment strategies for the statin intolerant patient.

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他汀类药物不耐受患者的管理
动脉粥样硬化性心血管疾病是发病率和死亡率的主要原因,他汀类药物已成为其治疗和预防的基石。尽管他汀类药物有充分的益处,但许多患者停止服用,肌肉不良症状是常见的原因。尽管一些他汀类药物相关的肌肉不良反应是真实存在的,但有些可归因于nocebo效应,即患者对伤害的感知。本文的目的是回顾他汀类药物安全性的文献,特别是与肌肉相关的文献,分析不良反应,并提出他汀类药物不耐受患者的各种治疗策略。
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来源期刊
CiteScore
11.90
自引率
0.00%
发文量
77
审稿时长
6-12 weeks
期刊介绍: Best Practice & Research Clinical Endocrinology & Metabolism is a serial publication that integrates the latest original research findings into evidence-based review articles. These articles aim to address key clinical issues related to diagnosis, treatment, and patient management. Each issue adopts a problem-oriented approach, focusing on key questions and clearly outlining what is known while identifying areas for future research. Practical management strategies are described to facilitate application to individual patients. The series targets physicians in practice or training.
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