{"title":"The Long and Winding Road to the Best Clinical Research and Personalized Therapy With Probiotics: Do Not Forget Host Physiology.","authors":"Yong Sung Kim, Suck Chei Choi","doi":"10.5056/jnm23034","DOIUrl":null,"url":null,"abstract":"host-specific factors such as gut transit time and gut microbiota composition determines the persistence of ingested probiotics. This study suggests several implications for clinicians and researchers using probiotics. The first is the difficulty in clinical research conducted using a probiotic. The results of previously re-ported clinical trials with probiotics are heterogeneous, even in the same disease, such as irritable bowel syndrome. 5 The claimed effects of probiotics have recently been questioned owing to the low quality of previous clinical trials by current stringent methodological standards. The low concordance between clinical studies using probiotics was mainly due to their characteristics. To date, a wide variety of","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/7e/jnm-29-2-129.PMC10083108.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neurogastroenterology and Motility","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5056/jnm23034","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
host-specific factors such as gut transit time and gut microbiota composition determines the persistence of ingested probiotics. This study suggests several implications for clinicians and researchers using probiotics. The first is the difficulty in clinical research conducted using a probiotic. The results of previously re-ported clinical trials with probiotics are heterogeneous, even in the same disease, such as irritable bowel syndrome. 5 The claimed effects of probiotics have recently been questioned owing to the low quality of previous clinical trials by current stringent methodological standards. The low concordance between clinical studies using probiotics was mainly due to their characteristics. To date, a wide variety of
期刊介绍:
Journal of Neurogastroenterology and Motility (J Neurogastroenterol Motil) is a joint official journal of the Korean Society of Neurogastroenterology and Motility, the Thai Neurogastroenterology and Motility Society, the Japanese Society of Neurogastroenterology and Motility, the Indian Motility and Functional Disease Association, the Chinese Society of Gastrointestinal Motility, the South East Asia Gastro-Neuro Motility Association, the Taiwan Neurogastroenterology and Motility Society and the Asian Neurogastroenterology and Motility Association, launched in January 2010 after the title change from the Korean Journal of Neurogastroenterology and Motility, published from 1994 to 2009.