Evaluation of diffuse lymphadenopathy via various quantitative PET/CT parameters.

IF 0.9 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Hellenic journal of nuclear medicine Pub Date : 2023-01-01 DOI:10.1967/s002449912555

Güler Silov, Emel Çankaya, Seyhan Karaçavuş

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Abstract

Objective: Discovery of diffuse lymphadenopathy (DLAP) in fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) imaging alerts for the existence of many pathologic conditions with severity ranging from benign to malignancy. This study examines the role of various metabolic parameters reflecting ¹⁸F-FDG characteristics of organs/tissues to reach an accurate differential diagnosis for further clinical assessment.

Materials and methods: Positron emission tomography/CT images of 78 patients with DLAP were reviewed retrospectively. The diameter of the largest lymph node (DLlyn), maximum standardized uptake value (SUVmax) of the liver (L), the largest lymph node (Llyn), spleen (S), and bone marrow (BM) were measured. Ratios to liver SUVmax were calculated for all, resulting LLRmax, SLRmax, and BMLRmax respectively.

Results: The diameter of the largest lymph node, Llyn.SUVmax, LLRmax, and SLRmax produced cut-off values as 25.5, 8.86, 2.80, and 0.82 with corresponding sensitivity:specificity values as 65%:83%, 74%:77%, 74%:71%, and 79%:63% respectively for risk stratification of malignant causes. To differentiate lymphoma from sarcoidosis, DLlyn, SLRmax, and BMLRmax were found valuable with cut-off values obtained as 28.5, 0.84, and 1.19 with corresponding sensitivity:specificity values as 79%:91%, 79%:82%, and 54%:91%, respectively.Interdependency between parameters was also evaluated.

Conclusion: High values of Llyn.Maximum SUV and LLRmax are the main characteristics of lymphoma, metastasis, and sarcoidosis. The diameter of the largest lymph node, SLRmax, and BMLRmax are determined as distinct parameters for distinguishing lymphoma from sarcoidosis. Besides, observed correlation structures amongst some PET/CT parameters were identified as nodal, extranodal, and diffuse patterns for three disease groups except sarcoidosis. These findings extend the knowledge about diagnostic factors based on ¹⁸F-FDG PET/CT patterns for DLAP.

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通过各种定量PET/CT参数评估弥漫性淋巴结病。

目的:在氟-18-氟脱氧葡萄糖(18F-FDG)正电子发射断层扫描/计算机断层扫描(PET/CT)成像中发现弥漫性淋巴结病(DLAP)，提示存在多种严重程度从良性到恶性的病理状况。本研究探讨了反映器官/组织18F-FDG特征的各种代谢参数的作用，以达到准确的鉴别诊断，以进一步进行临床评估。材料与方法:回顾性分析78例DLAP患者的正电子发射断层扫描/CT图像。测定最大淋巴结直径(dlar)、肝脏最大标准化摄取值(SUVmax) (L)、最大淋巴结(Llyn)、脾脏(S)、骨髓(BM)。计算所有动物与肝脏SUVmax的比值，分别得到LLRmax、SLRmax和BMLRmax。结果:最大淋巴结直径Llyn。SUVmax、LLRmax和SLRmax的危险分层临界值分别为25.5、8.86、2.80和0.82，相应的敏感性和特异性分别为65%:83%、74%:77%、74%:71%和79%:63%。为了区分淋巴瘤和结节病，dlar、SLRmax和BMLRmax有价值，其临界值分别为28.5、0.84和1.19，相应的敏感性和特异性分别为79%:91%、79%:82%和54%:91%。还评估了参数之间的相互依赖性。结论:Llyn具有较高的应用价值。最大SUV和LLRmax是淋巴瘤、转移和结节病的主要特征。最大淋巴结的直径，SLRmax和BMLRmax被确定为区分淋巴瘤和结节病的不同参数。此外，观察到的PET/CT参数之间的相关结构在除结节病外的三组疾病中被确定为淋巴结，结外和弥漫性模式。这些发现扩展了基于18F-FDG PET/CT模式的DLAP诊断因素的知识。

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来源期刊

Hellenic journal of nuclear medicine 医学-核医学

CiteScore

1.40

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： The Hellenic Journal of Nuclear Medicine published by the Hellenic Society of Nuclear Medicine in Thessaloniki, aims to contribute to research, to education and cover the scientific and professional interests of physicians, in the field of nuclear medicine and in medicine in general. The journal may publish papers of nuclear medicine and also papers that refer to related subjects as dosimetry, computer science, targeting of gene expression, radioimmunoassay, radiation protection, biology, cell trafficking, related historical brief reviews and other related subjects. Original papers are preferred. The journal may after special agreement publish supplements covering important subjects, dully reviewed and subscripted separately.