Chemical constituents from Ficus sur Forssk (Moraceae).

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2023-05-25 DOI:10.1515/znc-2022-0165

Eitel Ngoh Misse Mouelle, Mohamed Foundikou Nsangou, Vanini Samiyatou Michiren Mandou, Jean Duplex Wansi, Sergi Herve Akone, Emmanuel Ngeufa Happi

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引用次数: 1

Abstract

Phytochemical investigation of the aerial roots of Ficus sur, a Cameroonian medicinal plant, resulted in a previously undescribed cerebroside, suroside (1), in addition to its aglycon congener suramide (2). Moreover, six known natural products including alpinumisoflavone (3), wighteone metabolite (4), oleanolic acid (5), β-sitosterol (6), β-sitosterol-3-O-β-D-glucopyranoside (7), and epi-ѱ-taraxastanolone (8) were identified. The structures of the previously undescribed compounds were determined by analysis of 1D and 2D-NMR (One and two dimensional nuclear magnetic resonance), mass spectrometry, chemical conversion, and by comparison of these data with those from the literature. Wighteone metabolite (4) exhibited a weak cytotoxic activity against the human HepG2 hepatocellular carcinoma cells with an IC₅₀ value of 51.9 µM.

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桑科无花果的化学成分。

对喀麦隆药用植物Ficus sur的气生根进行植物化学研究，发现了一种以前未被描述过的脑苷，suroside(1)，以及其糖醛酸同属物suramide(2)。此外，还鉴定了六种已知的天然产物，包括alpinumisoflavone(3)，白豆酮代谢物(4)，齐ole果酸(5)，β-谷甾醇(6)，β-谷甾醇-3- o -β-D-glucopyranoside(7)和epi-ѱ-taraxastanolone(8)。通过1D和2d核磁共振(一维和二维核磁共振)、质谱分析、化学转化分析以及与文献数据的比较，确定了先前描述的化合物的结构。怀特酮代谢物(4)对人HepG2肝癌细胞具有较弱的细胞毒活性，IC50值为51.9µM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences 生物-生化与分子生物学

CiteScore

4.10

自引率

5.00%

发文量

期刊介绍： A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal and a community resource for the emerging field of natural and natural-like products. The journal publishes original research on the isolation (including structure elucidation), bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and their biological activity and innovative developed computational methods for predicting the structure and/or function of natural products. A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) welcomes research papers in fields on the chemistry-biology boundary which address scientific ideas and approaches to generate and understand natural compounds on a molecular level and/or use them to stimulate and manipulate biological processes.