Heart Disease and Ageing: The Roles of Senescence, Mitochondria, and Telomerase in Cardiovascular Disease.

Q1 Biochemistry, Genetics and Molecular Biology Sub-cellular biochemistry Pub Date : 2023-01-01 DOI:10.1007/978-3-031-26576-1_4

Laura K Booth, Rachael E Redgrave, Simon Tual-Chalot, Ioakim Spyridopoulos, Helen M Phillips, Gavin D Richardson

{"title":"Heart Disease and Ageing: The Roles of Senescence, Mitochondria, and Telomerase in Cardiovascular Disease.","authors":"Laura K Booth, Rachael E Redgrave, Simon Tual-Chalot, Ioakim Spyridopoulos, Helen M Phillips, Gavin D Richardson","doi":"10.1007/978-3-031-26576-1_4","DOIUrl":null,"url":null,"abstract":"<p><p>During ageing molecular damage leads to the accumulation of several hallmarks of ageing including mitochondrial dysfunction, cellular senescence, genetic instability and chronic inflammation, which contribute to the development and progression of ageing-associated diseases including cardiovascular disease. Consequently, understanding how these hallmarks of biological ageing interact with the cardiovascular system and each other is fundamental to the pursuit of improving cardiovascular health globally. This review provides an overview of our current understanding of how candidate hallmarks contribute to cardiovascular diseases such as atherosclerosis, coronary artery disease and subsequent myocardial infarction, and age-related heart failure. Further, we consider the evidence that, even in the absence of chronological age, acute cellular stress leading to accelerated biological ageing expedites cardiovascular dysfunction and impacts on cardiovascular health. Finally, we consider the opportunities that modulating hallmarks of ageing offer for the development of novel cardiovascular therapeutics.</p>","PeriodicalId":21991,"journal":{"name":"Sub-cellular biochemistry","volume":"103 ","pages":"45-78"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sub-cellular biochemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-3-031-26576-1_4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}

引用次数: 0

Abstract

During ageing molecular damage leads to the accumulation of several hallmarks of ageing including mitochondrial dysfunction, cellular senescence, genetic instability and chronic inflammation, which contribute to the development and progression of ageing-associated diseases including cardiovascular disease. Consequently, understanding how these hallmarks of biological ageing interact with the cardiovascular system and each other is fundamental to the pursuit of improving cardiovascular health globally. This review provides an overview of our current understanding of how candidate hallmarks contribute to cardiovascular diseases such as atherosclerosis, coronary artery disease and subsequent myocardial infarction, and age-related heart failure. Further, we consider the evidence that, even in the absence of chronological age, acute cellular stress leading to accelerated biological ageing expedites cardiovascular dysfunction and impacts on cardiovascular health. Finally, we consider the opportunities that modulating hallmarks of ageing offer for the development of novel cardiovascular therapeutics.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

心脏病与衰老：衰老、线粒体和端粒酶在心血管疾病中的作用。

在衰老过程中，分子损伤会导致线粒体功能障碍、细胞衰老、遗传不稳定性和慢性炎症等几种衰老标志的积累，从而导致包括心血管疾病在内的衰老相关疾病的发生和发展。因此，了解这些生物老化标志如何与心血管系统相互作用，对于在全球范围内改善心血管健康至关重要。本综述概述了我们目前对候选特征如何导致动脉粥样硬化、冠状动脉疾病及随后的心肌梗塞和老年性心力衰竭等心血管疾病的理解。此外，我们还考虑到有证据表明，即使没有生理年龄，急性细胞应激也会导致生物老化加速，从而加速心血管功能障碍并影响心血管健康。最后，我们探讨了调节老化特征为开发新型心血管疗法提供的机遇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Sub-cellular biochemistry Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

5.90

自引率

0.00%

发文量

期刊介绍： The book series SUBCELLULAR BIOCHEMISTRY is a renowned and well recognized forum for disseminating advances of emerging topics in Cell Biology and related subjects. All volumes are edited by established scientists and the individual chapters are written by experts on the relevant topic. The individual chapters of each volume are fully citable and indexed in Medline/Pubmed to ensure maximum visibility of the work.

期刊最新文献

Basic Epigenetic Mechanisms. Environmental Enrichment and Epigenetic Changes in the Brain: From the Outside to the Deep Inside. Epigenetic Control in Schizophrenia. Epigenetics in Learning and Memory. Epigenetics in Neurodegenerative Diseases.