Bronchoalveolar lavage cytology in children with chronic unexplained cough and severely neurologically impaired children.

Laboratory medicine Pub Date : 2024-01-06 DOI:10.1093/labmed/lmad028

Ivan Pavić, Draženka Ezgeta Karačić, Iva Hojsak

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Abstract

Objective: We aimed to compare the cellular composition of bronchoalveolar lavage (BAL) fluids in children with chronic unexplained cough (group 1) and severely neurologically impaired children with chronic or recurrent respiratory problems (group 2) with the BAL cytology of children without pulmonary or systemic diseases (group 3).

Methods: Bronchoscopy with BAL fluid analysis was performed in all subjects. Children with respiratory symptoms underwent 24-hour multichannel intraluminal impedance monitoring.

Results: A significant difference was found between the groups in the total number of cells in BAL fluid cytology (191 [range, 24-12,747], 747 [range, 53-13,000], and 105 [range, 41-233] cells/μL, P = .015), in the percentage of neutrophils (21.2 [SD = 32.4], 49.4 [SD = 36.6], and 3.6 [SD = 2.4], P < .001), and in the percentage of lipid-laden macrophages (10.3 [SD = 11.4], 13.7 [SD = 15.8] and 0.44 [SD = 1.0], P < .001).

Conclusion: The BAL fluid cytology provides useful data for determining the cause of chronic unexplained cough and chronic or recurrent respiratory problems in severely neurologically impaired children.

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慢性不明原因咳嗽患儿和严重神经受损患儿的支气管肺泡灌洗细胞学检查。

研究目的我们的目的是比较患有不明原因慢性咳嗽的儿童（第 1 组）和患有慢性或复发性呼吸系统疾病的严重神经受损儿童（第 2 组）的支气管肺泡灌洗液（BAL）细胞成分，以及无肺部或全身疾病儿童（第 3 组）的 BAL 细胞学情况：方法：对所有受试者进行支气管镜检查和 BAL 液分析。方法：对所有受试者进行支气管镜检查和 BAL 液分析，对有呼吸道症状的儿童进行 24 小时多通道腔内阻抗监测：结果：各组间在 BAL 液细胞学检查中细胞总数（191 [范围，24-12,747]、747 [范围，53-13,000]和 105 [范围，41-233] 个/μL，P = .结论：痰液细胞学检查可为患者提供更多的信息，包括：痰液中中性粒细胞的百分比（21.2 [SD = 32.4]、49.4 [SD = 36.6]和 3.6 [SD = 2.4]，P < .001）；痰液中脂质巨噬细胞的百分比（10.3 [SD = 11.4]、13.7 [SD = 15.8]和 0.44 [SD = 1.0]，P < .001）：BAL 液细胞学检查为确定严重神经受损儿童不明原因的慢性咳嗽、慢性或反复呼吸道问题的原因提供了有用的数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Laboratory medicine

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