Systems Biology of Virus-Host Protein Interactions: From Hypothesis Generation to Mechanisms of Replication and Pathogenesis.

IF 8.1 1区 医学 Q1 VIROLOGY Annual Review of Virology Pub Date : 2022-09-29 DOI:10.1146/annurev-virology-100520-011851
Priya S Shah, Nitin S Beesabathuni, Adam T Fishburn, Matthew W Kenaston, Shiaki A Minami, Oanh H Pham, Inglis Tucker
{"title":"Systems Biology of Virus-Host Protein Interactions: From Hypothesis Generation to Mechanisms of Replication and Pathogenesis.","authors":"Priya S Shah,&nbsp;Nitin S Beesabathuni,&nbsp;Adam T Fishburn,&nbsp;Matthew W Kenaston,&nbsp;Shiaki A Minami,&nbsp;Oanh H Pham,&nbsp;Inglis Tucker","doi":"10.1146/annurev-virology-100520-011851","DOIUrl":null,"url":null,"abstract":"<p><p>As obligate intracellular parasites, all viruses must co-opt cellular machinery to facilitate their own replication. Viruses often co-opt these cellular pathways and processes through physical interactions between viral and host proteins. In addition to facilitating fundamental aspects of virus replication cycles, these virus-host protein interactions can also disrupt physiological functions of host proteins, causing disease that can be advantageous to the virus or simply a coincidence. Consequently, unraveling virus-host protein interactions can serve as a window into molecular mechanisms of virus replication and pathogenesis. Identifying virus-host protein interactions using unbiased systems biology approaches provides an avenue for hypothesis generation. This review highlights common systems biology approaches for identification of virus-host protein interactions and the mechanistic insights revealed by these methods. We also review conceptual innovations using comparative and integrative systems biology that can leverage global virus-host protein interaction data sets to more rapidly move from hypothesis generation to mechanism.</p>","PeriodicalId":48761,"journal":{"name":"Annual Review of Virology","volume":"9 1","pages":"397-415"},"PeriodicalIF":8.1000,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150767/pdf/nihms-1891242.pdf","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual Review of Virology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1146/annurev-virology-100520-011851","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VIROLOGY","Score":null,"Total":0}
引用次数: 4

Abstract

As obligate intracellular parasites, all viruses must co-opt cellular machinery to facilitate their own replication. Viruses often co-opt these cellular pathways and processes through physical interactions between viral and host proteins. In addition to facilitating fundamental aspects of virus replication cycles, these virus-host protein interactions can also disrupt physiological functions of host proteins, causing disease that can be advantageous to the virus or simply a coincidence. Consequently, unraveling virus-host protein interactions can serve as a window into molecular mechanisms of virus replication and pathogenesis. Identifying virus-host protein interactions using unbiased systems biology approaches provides an avenue for hypothesis generation. This review highlights common systems biology approaches for identification of virus-host protein interactions and the mechanistic insights revealed by these methods. We also review conceptual innovations using comparative and integrative systems biology that can leverage global virus-host protein interaction data sets to more rapidly move from hypothesis generation to mechanism.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
病毒-宿主蛋白相互作用的系统生物学:从假说的产生到复制和发病机制。
作为专性细胞内寄生虫,所有病毒都必须利用细胞机制来促进自身的复制。病毒通常通过病毒和宿主蛋白之间的物理相互作用来利用这些细胞途径和过程。除了促进病毒复制周期的基本方面外,这些病毒-宿主蛋白质相互作用还可以破坏宿主蛋白质的生理功能,导致对病毒有利的疾病或仅仅是巧合。因此,解开病毒与宿主蛋白的相互作用可以作为了解病毒复制和发病机制的分子机制的窗口。使用无偏系统生物学方法鉴定病毒-宿主蛋白相互作用为假设生成提供了一条途径。这篇综述强调了鉴定病毒-宿主蛋白相互作用的常见系统生物学方法以及这些方法揭示的机制见解。我们还回顾了使用比较和综合系统生物学的概念创新,这些概念创新可以利用全球病毒-宿主蛋白相互作用数据集,更快地从假设生成转向机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
期刊最新文献
Bacteriophage T4 as a Protein-Based, Adjuvant- and Needle-Free, Mucosal Pandemic Vaccine Design Platform. Embracing Complexity: What Novel Sequencing Methods Are Teaching Us About Herpesvirus Genomic Diversity. From Entry to the Nucleus: How Retroviruses Commute. The Cold War and Phage Therapy: How Geopolitics Stalled Development of Viruses as Antibacterials. The Molecular Maze of Potyviral and Host Protein Interactions.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1