Copy number variation of the ZNF679 gene in cattle and its association analysis with growth traits.

IF 1.7 3区农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Animal Biotechnology Pub Date : 2023-12-01 Epub Date: 2023-04-24 DOI:10.1080/10495398.2023.2185628

Xingya Song, Xinmiao Li, Xian Liu, Zijing Zhang, Xiaoting Ding, Yanan Chai, Zhiming Li, Hongli Wang, Jungang Li, Huifeng Liang, Xiaoyan Sun, Guojie Yang, Zengfang Qi, Fuying Chen, Qiaoting Shi, Eryao Wang, Baorui Ru, Chuzhao Lei, Hong Chen, Wujun Liu, Yongzhen Huang

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Abstract

Copy number variation (CNV) is an important member of genetic structural variation that exists widely in animal genomes and is between 50 bp and several Mb in length and widely used in research's of animal genetics and breeding. ZNF679 is an important transcription factor, which has been found association with diseases in the human genome many times. This gene has also been found to be associated with cattle growth traits in previous re-sequencing studies. We tested the CNVs of the ZNF679 gene in 809 individuals from 7 Chinese cattle breeds and tested the association between the CNVs and growth traits in 552 individuals from 5 breeds. The results demonstrated the correlation the correlation between the CNVs of the ZNF679 gene and some Chinese cattle (QC cattle and XN cattle) growth traits. To sum up, this study indicated that ZNF679-CNVs can be used as a candidate gene for molecular genetic marker-assisted selection breeding for cattle growth traits to contribute to the development of genetic improvement of Chinese cattle.

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牛 ZNF679 基因的拷贝数变异及其与生长性状的关联分析

拷贝数变异（CNV）是遗传结构变异的一个重要成员，广泛存在于动物基因组中，长度在 50 bp 至数个 Mb 之间，被广泛应用于动物遗传学和育种研究中。ZNF679 是一个重要的转录因子，在人类基因组中多次被发现与疾病相关。在以往的重测序研究中，该基因也被发现与牛的生长性状有关。我们检测了中国 7 个牛种 809 头牛的 ZNF679 基因 CNVs，并检测了 5 个牛种 552 头牛的 CNVs 与生长性状的相关性。结果表明，ZNF679 基因的 CNVs 与中国牛（QC 牛和 XN 牛）的某些生长性状存在相关性。综上所述，本研究表明 ZNF679-CNVs 可作为候选基因用于牛生长性状的分子遗传标记辅助选择育种，为中国牛遗传改良的发展做出贡献。

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来源期刊

Animal Biotechnology 工程技术-奶制品与动物科学

CiteScore

2.90

自引率

5.40%

发文量

230

审稿时长

>12 weeks

期刊介绍： Biotechnology can be defined as any technique that uses living organisms (or parts of organisms like cells, genes, proteins) to make or modify products, to improve plants, animals or microorganisms for a specific use. Animal Biotechnology publishes research on the identification and manipulation of genes and their products, stressing applications in domesticated animals. The journal publishes full-length articles and short research communications, as well as comprehensive reviews. The journal also provides a forum for regulatory or scientific issues related to cell and molecular biology applied to animal biotechnology. Submissions on the following topics are particularly welcome: - Applied microbiology, immunogenetics and antibiotic resistance - Genome engineering and animal models - Comparative genomics - Gene editing and CRISPRs - Reproductive biotechnologies - Synthetic biology and design of new genomes