BioAFMviewer software for simulation atomic force microscopy of molecular structures and conformational dynamics

IF 3.5 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Structural Biology: X Pub Date : 2023-01-01 DOI:10.1016/j.yjsbx.2023.100086
Romain Amyot , Noriyuki Kodera, Holger Flechsig
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引用次数: 1

Abstract

Atomic force microscopy (AFM) and high-speed scanning have significantly advanced real time observation of biomolecular dynamics, with applications ranging from single molecules to the cellular level. To facilitate the interpretation of resolution-limited imaging, post-experimental computational analysis plays an increasingly important role to understand AFM measurements. Data-driven simulation of AFM, computationally emulating experimental scanning, and automatized fitting has recently elevated the understanding of measured AFM topographies by inferring the underlying full 3D atomistic structures. Providing an interactive user-friendly interface for simulation AFM, the BioAFMviewer software has become an established tool within the Bio-AFM community, with a plethora of applications demonstrating how the obtained full atomistic information advances molecular understanding beyond topographic imaging. This graphical review illustrates the BioAFMviewer capacities and further emphasizes the importance of simulation AFM to complement experimental observations.

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BioAFMviewer软件用于模拟分子结构和构象动力学的原子力显微镜
原子力显微镜(AFM)和高速扫描极大地推进了生物分子动力学的实时观察,其应用范围从单分子到细胞水平。为了方便解释分辨率有限的成像,实验后计算分析在理解AFM测量中起着越来越重要的作用。最近,数据驱动的AFM模拟、计算模拟实验扫描和自动化拟合,通过推断潜在的完整3D原子结构,提高了对AFM测量地形的理解。BioAFMviewer软件为模拟AFM提供了一个交互式的用户友好界面,已成为Bio-AFM社区的一个成熟工具,大量的应用程序展示了获得的完整原子信息如何超越地形成像推进分子理解。这张图表说明了BioAFMviewer的能力,并进一步强调了模拟AFM对补充实验观察的重要性。
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来源期刊
Journal of Structural Biology: X
Journal of Structural Biology: X Biochemistry, Genetics and Molecular Biology-Structural Biology
CiteScore
6.50
自引率
0.00%
发文量
20
审稿时长
62 days
期刊最新文献
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