Diagnosis and Management of Pineal Germinoma: From Eye to Brain.

IF 3.1 Q1 OPHTHALMOLOGY Eye and Brain Pub Date : 2023-01-01 DOI:10.2147/EB.S389631
David Cohen, N Scott Litofsky
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Abstract

Pineal germinomas can be very complex in terms of presentation, diagnosis, and management. This review attempts to simplify this complexity in an organized manner, addressing the anatomic relationships that provide the basis for the uniqueness of pineal germinoma. Ocular findings and signs and symptoms of elevated intracranial pressure are the keys to suspecting the diagnosis and obtaining the necessary imaging and cerebrospinal fluid studies. Other symptoms can suggest spread beyond the pineal region. Surgery may only be needed to obtain tissue for a definitive diagnosis, as germinoma is highly responsive to chemotherapy and focused radiation therapy. Hydrocephalus, usually related to tumor obstruction of the cerebral aqueduct, may also need to be addressed. Outcome for pineal germinoma is usually excellent, but relapse can occur and may require additional intervention. These issues are detailed in this review.

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松果体生殖细胞瘤的诊断与治疗:从眼到脑。
松果体生殖细胞瘤在表现、诊断和治疗方面可能非常复杂。这篇综述试图以一种有组织的方式简化这种复杂性,解决松果体生殖细胞瘤的独特性提供基础的解剖关系。眼部表现和颅内压升高的体征和症状是怀疑诊断和获得必要的影像学和脑脊液检查的关键。其他症状可能表明扩散超出松果体区域。手术可能只需要获得明确诊断的组织,因为生殖细胞瘤对化疗和集中放射治疗高度敏感。脑积水,通常与肿瘤阻塞脑导水管有关,也可能需要解决。松果体生殖细胞瘤的预后通常很好,但可能会复发,需要额外的干预。这些问题将在本文中详细讨论。
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来源期刊
Eye and Brain
Eye and Brain OPHTHALMOLOGY-
CiteScore
7.90
自引率
2.30%
发文量
12
审稿时长
16 weeks
期刊介绍: Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.
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