Fertility preservation in women with benign gynaecological conditions.

IF 8.3 Q1 OBSTETRICS & GYNECOLOGY Human reproduction open Pub Date : 2023-01-01 DOI:10.1093/hropen/hoad012
Pietro Santulli, Christophe Blockeel, Mathilde Bourdon, Giovanni Coticchio, Alison Campbell, Michel De Vos, Kirsten Tryde Macklon, Anja Pinborg, Juan A Garcia-Velasco
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Abstract

Although a wealth of data has been published regarding fertility preservation (FP) in women with malignant diseases who receive gonadotoxic treatment, the role of FP in non-malignant conditions has been studied to a much lesser extent. These include benign haematological, autoimmune, and genetic disorders, as well as a multitude of benign gynaecological conditions (BGCs) that may compromise ovarian reserve and/or reproductive potential due to pathogenic mechanisms or as a result of medical or surgical treatments. Alongside accumulating data that document the reproductive potential of cryopreserved oocytes and ovarian tissue, there is potential interest in FP for women with BGCs at risk of infertility; however, there are currently insufficient data about FP in women with BGCs to develop guidelines for clinical practice. The purpose of this article is to appraise the available evidence regarding FP for BGC and discuss potential strategies for FP based on estimated ovarian impairment and on short-term and long-term reproductive goals of patients. Cost-effectiveness considerations and patients' perspectives will also be discussed.

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妇科良性疾病妇女的生育能力保存。
尽管已经发表了大量关于在患有恶性疾病的妇女中接受促性腺毒素治疗的生育能力保存(FP)的数据,但对FP在非恶性疾病中的作用的研究程度要小得多。这些疾病包括良性血液病、自身免疫性疾病和遗传性疾病,以及多种良性妇科疾病(BGCs),这些疾病可能由于致病机制或药物或手术治疗而损害卵巢储备和/或生殖潜力。除了积累记录冷冻保存的卵母细胞和卵巢组织的生殖潜力的数据外,对于有不孕风险的BGCs妇女,FP也有潜在的兴趣;然而,目前关于bgc妇女计划生育的数据不足,无法为临床实践制定指南。本文的目的是评估关于BGC的计划生育的现有证据,并根据估计的卵巢损害以及患者的短期和长期生殖目标讨论计划生育的潜在策略。成本效益的考虑和患者的观点也将讨论。
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