Predictive value of pathological carcinoma size in patients with T2 glottic laryngeal squamous cell carcinoma.

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY Acta Oto-Laryngologica Pub Date : 2023-04-01 DOI:10.1080/00016489.2023.2188083

Jian Zhou, Xiaoke Zhu, Yue Yang, Liang Zhou, Hongli Gong, Chengzhi Xu, Lei Tao

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Abstract

Background: T2N0M0 glottic laryngeal squamous cell carcinoma (LSCC) is a common type of laryngeal cancer.

Objectives: The objective of this research was to assess the predictive value of tumor size for the rates of overall survival (OS) and disease-free survival (DFS) as determined by postoperative pathological examination in patients with T2 LSCC.

Methods: A retrospective study was conducted on 535 successive patients with T2 glottic LSCC who underwent operation from 2005 to 2010. The effect of tumor size on OS and DFS results was evaluated by the affected area.

Results: Of the cohort, 528 (98.7%) were male, and 7 (1.3%) were female, with an average age of 60.1 ± 9.4 years. The 10-year DFS and OS rates were 72.1% and 76.3%, respectively. The tumor diameter and area cut-off values that best discriminated OS and DFS rates were 1.35 cm and 1 cm², respectively. Patients with glottis carcinoma with a longer tumor diameter and larger tumor area had inferior OS and DFS rates. Tumor diameter and tumor area were independent predictive factors for the rates of OS and DFS in patients with T2 glottic LSCC.

Conclusion and significance: This research showed that patients with T2 glottic LSCC with a carcinoma diameter >1.35 cm or a tumor area >1 cm² have worse survival outcomes. These factors independently predict survival outcomes in patients.

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病理癌大小对T2声门喉鳞癌的预测价值。

背景:T2N0M0声门喉部鳞状细胞癌(LSCC)是一种常见的喉癌。目的:本研究的目的是评估肿瘤大小对T2 LSCC患者术后病理检查确定的总生存率(OS)和无病生存率(DFS)的预测价值。方法:回顾性分析2005 ~ 2010年535例经手术治疗的T2声门LSCC患者的资料。肿瘤大小对OS和DFS结果的影响以受影响的面积来评价。结果:男性528例(98.7%)，女性7例(1.3%)，平均年龄60.1±9.4岁。10年DFS和OS分别为72.1%和76.3%。最能区分OS和DFS的肿瘤直径和面积临界值分别为1.35 cm和1 cm2。声门癌肿瘤直径较长、肿瘤面积较大的患者的OS和DFS均较低。肿瘤直径和肿瘤面积是T2声门LSCC患者OS和DFS发生率的独立预测因素。结论及意义:本研究显示癌直径>1.35 cm或肿瘤面积>1 cm2的T2声门LSCC患者生存预后较差。这些因素独立预测患者的生存结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Oto-Laryngologica 医学-耳鼻喉科学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

3-6 weeks

期刊介绍： Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.