Therapeutic Agent Delivery Across the Blood-Brain Barrier Using Focused Ultrasound.

IF 12.8 1区工程技术 Q1 ENGINEERING, BIOMEDICAL Annual Review of Biomedical Engineering Pub Date : 2021-07-13 DOI:10.1146/annurev-bioeng-062117-121238

Dallan McMahon, Meaghan A O'Reilly, Kullervo Hynynen

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引用次数: 30

Abstract

Specialized features of vasculature in the central nervous system greatly limit therapeutic treatment options for many neuropathologies. Focused ultrasound, in combination with circulating microbubbles, can be used to transiently and noninvasively increase cerebrovascular permeability with a high level of spatial precision. For minutes to hours following sonication, drugs can be administered systemically to extravasate in the targeted brain regions and exert a therapeutic effect, after which permeability returns to baseline levels. With the wide range of therapeutic agents that can be delivered using this approach and the growing clinical need, focused ultrasound and microbubble (FUS+MB) exposure in the brain has entered human testing to assess safety. This review outlines the use of FUS+MB-mediated cerebrovascular permeability enhancement as a drug delivery technique, details several technical and biological considerations of this approach, summarizes results from the clinical trials conducted to date, and discusses the future direction of the field.

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聚焦超声在血脑屏障传递治疗药物中的应用。

中枢神经系统脉管系统的特殊特征极大地限制了许多神经病变的治疗选择。聚焦超声结合循环微泡可瞬间无创增加脑血管通透性，具有较高的空间精度。超声检查后的几分钟到几小时内，药物可以全身给药，使目标脑区渗出，并发挥治疗作用，之后渗透性恢复到基线水平。随着广泛的治疗药物可以使用这种方法和不断增长的临床需求，聚焦超声和微泡(FUS+MB)暴露在大脑中已进入人体试验，以评估安全性。本文概述了FUS+ mb介导的脑血管通透性增强作为一种药物传递技术的应用，详细介绍了该方法的一些技术和生物学方面的考虑，总结了迄今为止进行的临床试验的结果，并讨论了该领域的未来方向。

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来源期刊

Annual Review of Biomedical Engineering 工程技术-工程：生物医学

CiteScore

18.80

自引率

0.00%

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期刊介绍： Since 1999, the Annual Review of Biomedical Engineering has been capturing major advancements in the expansive realm of biomedical engineering. Encompassing biomechanics, biomaterials, computational genomics and proteomics, tissue engineering, biomonitoring, healthcare engineering, drug delivery, bioelectrical engineering, biochemical engineering, and biomedical imaging, the journal remains a vital resource. The current volume has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.