Rebound Hypoglycemia and Hyperglycemia in Type 1 Diabetes.

IF 4.1 Q2 ENDOCRINOLOGY & METABOLISM Journal of Diabetes Science and Technology Pub Date : 2024-11-01 Epub Date: 2023-05-03 DOI:10.1177/19322968231168379
Klavs W Hansen, Bo M Bibby
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Abstract

Aims: The aim was to investigate rebound hypoglycemic and hyperglycemic events, and describe their relation to other glycemic metrics.

Methods: Data from intermittently scanned continuous glucose monitoring were downloaded for 90 days for 159 persons with type 1 diabetes. A hypoglycemic event was defined as glucose <3.9 mmol/l for at least two 15-minute periods. Rebound hypoglycemia (Rhypo) was a hypoglycemic event preceded by glucose >10.0 mmol/l within 120 minutes and rebound hyperglycemia (Rhyper) was hypoglycemia followed by glucose >10.0 mmol/l within 120 minutes.

Results: A total of 10 977 hypoglycemic events were identified of which 3232 (29%) were Rhypo and 3653 (33%) were Rhyper, corresponding to a median frequency of 10.1, 2.5, and 3.0 events per person/14 days. For 1267 (12%) of the cases, Rhypo and Rhyper coexisted. The mean peak glucose was 13.0 ± 1.6 mmol/l before Rhypo; 12.8 ± 1.1 mmol/l in Rhyper. The frequency of Rhyper was significantly (P < .001) correlated with Rhypo (Spearman's rho 0.84), glucose coefficient of variation (0.78), and time below range (0.69) but not with time above range (0.12, P = .13).

Conclusions: The strong correlation between Rhyper and Rhypo suggests an individual behavioral characteristic toward intensive correction of glucose excursions.

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1 型糖尿病患者的反跳性低血糖症和高血糖症。
目的:旨在调查反跳性低血糖和高血糖事件,并描述其与其他血糖指标的关系:下载了 159 名 1 型糖尿病患者 90 天的间歇扫描连续血糖监测数据。低血糖事件定义为 120 分钟内血糖为 10.0 毫摩尔/升,反跳性高血糖(Rhyper)定义为低血糖后 120 分钟内血糖>10.0 毫摩尔/升:共发现 10 977 起低血糖事件,其中 3232 起(29%)为 Rhypo,3653 起(33%)为 Rhyper,中位频率分别为每人 10.1 次、2.5 次和 3.0 次/14 天。在 1267 例(12%)病例中,Rhypo 和 Rhyper 同时存在。Rhypo 前的平均峰值血糖为 13.0 ± 1.6 mmol/l;Rhyper 时为 12.8 ± 1.1 mmol/l。Rhyper 频率与 Rhypo(Spearman's rho 0.84)、血糖变异系数(0.78)和低于范围的时间(0.69)显著相关(P < .001),但与高于范围的时间(0.12,P = .13)不相关:结论:Rhyper 和 Rhypo 之间的强相关性表明,强化纠正血糖偏移是一种个体行为特征。
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来源期刊
Journal of Diabetes Science and Technology
Journal of Diabetes Science and Technology Medicine-Internal Medicine
CiteScore
7.50
自引率
12.00%
发文量
148
期刊介绍: The Journal of Diabetes Science and Technology (JDST) is a bi-monthly, peer-reviewed scientific journal published by the Diabetes Technology Society. JDST covers scientific and clinical aspects of diabetes technology including glucose monitoring, insulin and metabolic peptide delivery, the artificial pancreas, digital health, precision medicine, social media, cybersecurity, software for modeling, physiologic monitoring, technology for managing obesity, and diagnostic tests of glycation. The journal also covers the development and use of mobile applications and wireless communication, as well as bioengineered tools such as MEMS, new biomaterials, and nanotechnology to develop new sensors. Articles in JDST cover both basic research and clinical applications of technologies being developed to help people with diabetes.
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