Systems Immunology Approaches to Metabolism.

IF 26.9 1区 医学 Q1 IMMUNOLOGY Annual review of immunology Pub Date : 2023-04-26 DOI:10.1146/annurev-immunol-101220-031513
Denis A Mogilenko, Alexey Sergushichev, Maxim N Artyomov
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Abstract

Over the last decade, immunometabolism has emerged as a novel interdisciplinary field of research and yielded significant fundamental insights into the regulation of immune responses. Multiple classical approaches to interrogate immunometabolism, including bulk metabolic profiling and analysis of metabolic regulator expression, paved the way to appreciating the physiological complexity of immunometabolic regulation in vivo. Studying immunometabolism at the systems level raised the need to transition towards the next-generation technology for metabolic profiling and analysis. Spatially resolved metabolic imaging and computational algorithms for multi-modal data integration are new approaches to connecting metabolism and immunity. In this review, we discuss recent studies that highlight the complex physiological interplay between immune responses and metabolism and give an overview of technological developments that bear the promise of capturing this complexity most directly and comprehensively.

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代谢的系统免疫学方法。
在过去的十年中,免疫代谢已经成为一个新的跨学科研究领域,并对免疫反应的调节产生了重要的基础见解。研究免疫代谢的多种经典方法,包括大量代谢谱分析和代谢调节因子表达分析,为认识体内免疫代谢调节的生理复杂性铺平了道路。在系统水平上研究免疫代谢提出了向下一代代谢分析和分析技术过渡的需要。空间分辨代谢成像和多模态数据集成计算算法是连接代谢与免疫的新途径。在这篇综述中,我们讨论了最近的研究,强调了免疫反应和代谢之间复杂的生理相互作用,并概述了技术的发展,这些技术有望最直接和全面地捕捉这种复杂性。
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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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