Gene and schizophrenia in the pregenome and postgenome-wide association studies era: a bibliometric analysis and network visualization.

IF 1.5 4区医学 Q4 GENETICS & HEREDITY Psychiatric Genetics Pub Date : 2023-04-01 Epub Date: 2023-02-23 DOI:10.1097/YPG.0000000000000336

Wan Nur Amalina Zakaria, Teguh Haryo Sasongko, Badryia Al-Rahbi, Noorah Al-Sowayan, Asma Hayati Ahmad, Rahimah Zakaria, Aidi Ahmi, Zahiruddin Othman

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Abstract

This study aimed to perform a bibliometric analysis on genetic studies in schizophrenia in the pregenome-wide association studies (GWAS) and post-GWAS era. We searched the literature on genes and schizophrenia using the Scopus database. The documents increased with time, especially after the human genome project and International HapMap Project, with the highest citation in 2008. The top occurrence author keywords were discovered to be different in the pre-GWAS and post-GWAS eras, reflecting the progress of genetic studies connected to schizophrenia. Emerging keywords highlighted a trend towards an application of precision medicine, showing an interplay of environmental exposures as well as genetic factors in schizophrenia pathogenesis, progression, and response to therapy. In conclusion, the gene and schizophrenia literature has grown rapidly after the human genome project, and the temporal variation in the author keywords pattern reflects the trend of genetic studies related to schizophrenia in the pre-GWAS and post-GWAS era.

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基因组前和基因组后关联研究时代的基因和精神分裂症：文献计量分析和网络可视化。

本研究旨在对孕基因组广泛关联研究（GWAS）和后GWAS时代精神分裂症的遗传学研究进行文献计量学分析。我们使用Scopus数据库检索了有关基因和精神分裂症的文献。这些文献随着时间的推移而增加，尤其是在人类基因组计划和国际HapMap计划之后，2008年的引用量最高。研究发现，在GWAS之前和之后的时代，最常见的作者关键词是不同的，这反映了与精神分裂症相关的遗传学研究的进展。新兴的关键词突出了精准医学的应用趋势，显示了环境暴露以及遗传因素在精神分裂症发病机制、进展和治疗反应中的相互作用。总之，在人类基因组计划之后，基因和精神分裂症文献迅速增长，作者关键词模式的时间变化反映了前GWAS和后GWAS时代与精神分裂症相关的遗传学研究的趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.