Myostatin: A Skeletal Muscle Chalone.

IF 15.7 1区 医学 Q1 PHYSIOLOGY Annual review of physiology Pub Date : 2023-02-10 DOI:10.1146/annurev-physiol-012422-112116
Se-Jin Lee
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引用次数: 10

Abstract

Myostatin (GDF-8) was discovered 25 years ago as a new transforming growth factor-β family member that acts as a master regulator of skeletal muscle mass. Myostatin is made by skeletal myofibers, circulates in the blood, and acts back on myofibers to limit growth. Myostatin appears to have all of the salient properties of a chalone, which is a term proposed over a half century ago to describe hypothetical circulating, tissue-specific growth inhibitors that control tissue size. The elucidation of the molecular, cellular, and physiological mechanisms underlying myostatin activity suggests that myostatin functions as a negative feedback regulator of muscle mass and raises the question as to whether this type of chalone mechanism is unique to skeletal muscle or whether it also operates in other tissues.

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肌肉生长抑制素:一种骨骼肌抑制剂。
肌生长抑制素(GDF-8)是25年前发现的一种新的转化生长因子-β家族成员,作为骨骼肌质量的主要调节剂。肌肉生长抑制素由骨骼肌纤维产生,在血液中循环,并对肌纤维起反作用以限制其生长。肌生长抑制素似乎具有chalone的所有显著特性,chalone是半个多世纪前提出的一个术语,用来描述假设的循环,组织特异性生长抑制剂,控制组织大小。对肌肉生长抑制素活性的分子、细胞和生理机制的阐明表明,肌肉生长抑制素的功能是肌肉质量的负反馈调节器,并提出了这样一个问题:这种类型的chalone机制是骨骼肌独有的,还是它也在其他组织中起作用。
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来源期刊
Annual review of physiology
Annual review of physiology 医学-生理学
CiteScore
35.60
自引率
0.00%
发文量
41
期刊介绍: Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
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