Sphingolipid metabolism and its relationship with cardiovascular, renal and metabolic diseases.

IF 0.7 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Archivos de cardiologia de Mexico Pub Date : 2023-01-01 DOI:10.24875/ACM.21000333
Fernando Hernández-Bello, Martha Franco, Óscar Pérez-Méndez, Luis Donis-Maturano, Gabriela Zarco-Olvera, Rocío Bautista-Pérez
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引用次数: 1

Abstract

Sphingolipids (sphingomyelin, glycolipids, gangliosides) are located in cell membranes, plasma, and lipoproteins. In patients with cardiovascular, renal, and metabolic diseases, the profile of sphingolipids and their metabolites (ceramide, sphingosine, and sphingosine-1-phosphate) is modified, and these changes may explain the alterations in some cellular responses such as apoptosis. Furthermore, sphingosine and sphingosine-1-phosphate have been suggested to prevent COVID-19. This review also briefly mentions the techniques that allow us to study sphingolipids and their metabolites.

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鞘脂代谢及其与心血管、肾脏和代谢性疾病的关系。
鞘脂(鞘磷脂、糖脂、神经节苷)位于细胞膜、血浆和脂蛋白中。在心血管、肾脏和代谢性疾病患者中,鞘脂及其代谢物(神经酰胺、鞘氨醇和鞘氨醇-1-磷酸)的谱被改变,这些变化可能解释一些细胞反应的改变,如凋亡。此外,鞘氨醇和鞘氨醇-1-磷酸被认为可以预防COVID-19。本文还简要介绍了神经鞘脂及其代谢产物的研究技术。
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来源期刊
Archivos de cardiologia de Mexico
Archivos de cardiologia de Mexico Medicine-Cardiology and Cardiovascular Medicine
CiteScore
0.80
自引率
20.00%
发文量
176
审稿时长
18 weeks
期刊最新文献
[Assessment of coronary flow capacity by positron emission tomography in coronary artery disease]. [Acute myocardial infarction patients without COVID-19 manifestations in the pandemic may have high thrombus burden]. [Abnormal aortic origin of coronary arteries]. [Intracardiac leiomyoma]. [Comments to: Recommendations for the care of patients with heart failure and COVID-19].
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