Metabolically healthy obesity is associated with increased risk of lower urinary tract symptoms secondary to benign prostatic hyperplasia: A cohort study of Chinese elderly males

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY LUTS: Lower Urinary Tract Symptoms Pub Date : 2021-12-09 DOI:10.1111/luts.12420

Weinan Chen, Sailimai Man, Bo Wang, Gaohaer Kadeerhan, Xiaobo Huang

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引用次数: 1

Abstract

Objectives

Obesity and metabolic status are both modifiable risk factors of lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH). However, the association between metabolically healthy obesity (MHO) and LUTS/BPH is largely unexplored. This study aimed to investigate the risk of LUTS/BPH among different metabolic syndrome-body mass index (MetS-BMI) phenotypes in a cohort of Chinese males.

Methods

A total of 3321 males from the China Health and Retirement Longitudinal Study (CHARLS) without history of LUTS/BPH at baseline were included into the analyses. Participants were categorized into six mutually exclusive groups according to presence or absence of MetS combined with BMI status: metabolically healthy normal weight/overweight/obesity (MHN/MHOW/MHO) and metabolically unhealthy normal weight/overweight/obesity (MUN/MUOW/MUO). Adjusted odds ratios (OR) and 95% CI of LUTS/BPH across MetS-BMI categories were estimated with multivariable logistic regression models.

Results

A total of 394 (11.86%) participants developed LUTS/BPH during the follow-up. After adjusting for age, educational level, smoking status, drinking status, and BMI change, the multivariable-adjusted OR (95% CI) for incident LUTS/BPH comparing MUO, MHO, MUOW, MHOW, and MUN with MHN were 1.99 (1.23-3.22), 2.04 (1.14-3.66), 1.61 (1.11-2.34), 1.45 (1.02-2.05), and 0.91 (0.54-1.56), respectively.

Conclusions

MHO and MHOW were risk populations of LUTS/BPH, suggesting that overweight and obesity can independently contribute to LUTS/BPH, even among metabolically healthy individuals. These findings emphasize metabolically healthy individuals may still benefit from maintaining normal body weight to prevent LUTS/BPH. Our findings also support that those recommendations for LUTS/BPH should highlight the importance of maintaining metabolic health across all BMI groups among Chinese males.

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代谢健康的肥胖与继发于良性前列腺增生的下尿路症状的风险增加相关:一项针对中国老年男性的队列研究

肥胖和代谢状态都是良性前列腺增生(LUTS/BPH)继发下尿路症状的可改变危险因素。然而，代谢健康型肥胖(MHO)与LUTS/BPH之间的关系在很大程度上尚未被探索。本研究旨在探讨中国男性不同代谢综合征-体重指数(MetS-BMI)表型之间LUTS/BPH的风险。方法将中国健康与退休纵向研究(CHARLS)中无LUTS/BPH基线病史的3321名男性纳入分析。参与者根据是否存在MetS和BMI状态被分为六个相互排斥的组:代谢健康的正常体重/超重/肥胖(MHN/MHOW/MHO)和代谢不健康的正常体重/超重/肥胖(MUN/MUOW/MUO)。采用多变量logistic回归模型估计met - bmi类别中LUTS/BPH的校正优势比(OR)和95% CI。结果随访期间共394例(11.86%)发生LUTS/BPH。在调整了年龄、受教育程度、吸烟状况、饮酒状况和BMI变化后，MUO、MHO、MUOW、MHOW和MUN与MHN的LUTS/BPH事件的多变量调整OR (95% CI)分别为1.99(1.23-3.22)、2.04(1.14-3.66)、1.61(1.11-2.34)、1.45(1.02-2.05)和0.91(0.54-1.56)。结论MHO和MHOW是LUTS/BPH的危险人群，提示超重和肥胖可以独立促成LUTS/BPH，即使在代谢健康的个体中也是如此。这些发现强调，代谢健康的个体可能仍然受益于保持正常体重，以预防LUTS/BPH。我们的研究结果也支持这些关于LUTS/BPH的建议应该强调在所有BMI组中维持中国男性代谢健康的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

LUTS: Lower Urinary Tract Symptoms UROLOGY & NEPHROLOGY-

CiteScore

3.00

自引率

7.70%

发文量

审稿时长

>12 weeks

期刊介绍： LUTS is designed for the timely communication of peer-reviewed studies which provides new clinical and basic science information to physicians and researchers in the field of neurourology, urodynamics and urogynecology. Contributions are reviewed and selected by a group of distinguished referees from around the world, some of whom constitute the journal''s Editorial Board. The journal covers both basic and clinical research on lower urinary tract dysfunctions (LUTD), such as overactive bladder (OAB), detrusor underactivity, benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), urinary incontinence, pelvic organ prolapse (POP), painful bladder syndrome (PBS), as well as on other relevant conditions. Case reports are published only if new findings are provided. LUTS is an official journal of the Japanese Continence Society, the Korean Continence Society, and the Taiwanese Continence Society. Submission of papers from all countries are welcome. LUTS has been accepted into Science Citation Index Expanded (SCIE) with a 2011 Impact Factor.