Mechanotransduction and the endothelial glycocalyx: Interactions with membrane and cytoskeletal proteins to transduce force.

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology Current topics in membranes Pub Date : 2023-01-01 DOI:10.1016/bs.ctm.2023.02.003
Hassan Askari, Masoumeh Sadeghinejad, Ibra S Fancher
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引用次数: 2

Abstract

The endothelial glycocalyx is an extracellular matrix that coats the endothelium and extends into the lumen of blood vessels, acting as a barrier between the vascular wall and blood flowing through the vessel. This positioning of the glycocalyx permits a variety of its constituents, including the major endothelial proteoglycans glypican-1 and syndecan-1, as well as the major glycosaminoglycans heparan sulfate and hyaluronic acid, to contribute to the processes of mechanosensation and subsequent mechanotransduction following such stimuli as elevated shear stress. To coordinate the vast array of processes that occur in response to physical force, the glycocalyx interacts with a plethora of membrane and cytoskeletal proteins to carry out specific signaling pathways resulting in a variety of responses of endothelial cells and, ultimately, blood vessels to mechanical force. This review focuses on proposed glycocalyx-protein relationships whereby the endothelial glycocalyx interacts with a variety of membrane and cytoskeletal proteins to transduce force into a myriad of chemical signaling pathways. The established and proposed interactions at the molecular level are discussed in context of how the glycocalyx regulates membrane/cytoskeletal protein function in the many processes of endothelial mechanotransduction.

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机械转导和内皮糖萼:与膜和细胞骨架蛋白相互作用以转导力。
内皮糖萼是一种细胞外基质,覆盖在内皮细胞上并延伸到血管腔内,作为血管壁和血管内血液流动之间的屏障。糖萼的这种定位允许其多种成分,包括主要的内皮蛋白聚糖glyypican -1和syndecan-1,以及主要的糖胺聚糖肝素硫酸盐和透明质酸,在剪切应力升高等刺激下参与机械感觉和随后的机械转导过程。为了协调发生在物理力响应中的大量过程,糖萼与过多的膜和细胞骨架蛋白相互作用,以执行特定的信号通路,导致内皮细胞和最终血管对机械力的各种反应。这篇综述的重点是提出的糖萼与蛋白的关系,即内皮糖萼与各种膜和细胞骨架蛋白相互作用,将力转化为无数的化学信号通路。在内皮机械转导的许多过程中,糖萼如何调节膜/细胞骨架蛋白的功能,讨论了在分子水平上已建立和提出的相互作用。
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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
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