Several neuropeptides involved in parkinsonian neuroprotection modulate the firing properties of nigral dopaminergic neurons

IF 2.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Neuropeptides Pub Date : 2023-06-01 DOI:10.1016/j.npep.2023.102337

Lei Chen , Cui Liu , Yan Xue , Xin-Yi Chen

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引用次数: 3

Abstract

Parkinson's disease is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. The surviving nigral dopaminergic neurons display altered spontaneous firing activity in Parkinson's disease. The firing rate of nigral dopaminergic neurons decreases long before complete neuronal death and the appearance of parkinsonian symptoms. A mild stimulation could rescue dopaminergic neurons from death and in turn play neuroprotective effects. Several neuropeptides, including cholecystokinin (CCK), ghrelin, neurotensin, orexin, tachykinins and apelin, within the substantia nigra pars compacta play important roles in the modulation of spontaneous firing activity of dopaminergic neurons and therefore involve motor control and motor disorders. Here, we review neuropeptide-induced modulation of the firing properties of nigral dopaminergic neurons. This review may provide a background to guide further investigations into the involvement of neuropeptides in movement control by modulating firing activity of nigral dopaminergic neurons in Parkinson's disease.

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参与帕金森神经保护的几种神经肽调节黑质多巴胺能神经元的放电特性

帕金森病的特征是黑质致密部多巴胺能神经元的进行性变性。帕金森病中幸存的黑质多巴胺能神经元表现出改变的自发放电活动。黑质多巴胺能神经元的放电速率在神经元完全死亡和帕金森症状出现之前很久就降低了。轻度刺激可以使多巴胺能神经元免于死亡，进而发挥神经保护作用。黑质致密部内的几种神经肽，包括胆囊收缩素（CCK）、胃促生长素、神经降压素、食欲素、速激肽和apelin，在调节多巴胺能神经元的自发放电活动中发挥重要作用，因此涉及运动控制和运动障碍。在此，我们综述了神经肽诱导的黑质多巴胺能神经元放电特性的调节。这篇综述可能为进一步研究神经肽通过调节帕金森病中黑质多巴胺能神经元的放电活性参与运动控制提供背景。

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来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.