Pathophysiological Links Between Obesity and Dementia.

IF 3.3 4区 医学 Q2 NEUROSCIENCES NeuroMolecular Medicine Pub Date : 2023-12-01 Epub Date: 2023-04-22 DOI:10.1007/s12017-023-08746-1
David E Wong Zhang, Vivian Tran, Antony Vinh, Quynh Nhu Dinh, Grant R Drummond, Christopher G Sobey, Maria Jelinic, T Michael De Silva
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Abstract

Obesity is a major global health concern, with prevalence rates rapidly rising due to increased availability of highly processed foods rich in fats and/or sugars and technological advances promoting more sedentary behaviour. There is increasing evidence to suggest that obesity predisposes individuals to developing cognitive impairment and dementia. However, the relationship between the brain and the peripheral metabolic state is complex, and many of the underlying mechanisms of cognitive impairment in obesity are yet to be fully elucidated. To better understand the links between obesity and dementia, further work is required to determine pathological changes occurring in the brain during obesity. In this mini-review, we discuss the role of two pathological features of obesity (the gut-brain axis and systemic inflammation) and their potential contribution to dementia.

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肥胖症与痴呆症之间的病理生理学联系。
肥胖症是全球关注的一个主要健康问题,由于富含脂肪和/或糖的高度加工食品的供应量增加以及技术进步促进了更多的久坐行为,肥胖症的发病率迅速上升。越来越多的证据表明,肥胖容易导致认知障碍和痴呆症。然而,大脑与外周代谢状态之间的关系十分复杂,肥胖症导致认知障碍的许多潜在机制尚未完全阐明。为了更好地理解肥胖与痴呆症之间的联系,需要进一步开展工作,确定肥胖时大脑发生的病理变化。在这篇小型综述中,我们将讨论肥胖症的两个病理特征(肠道-大脑轴和全身炎症)的作用及其对痴呆症的潜在影响。
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来源期刊
NeuroMolecular Medicine
NeuroMolecular Medicine 医学-神经科学
CiteScore
7.10
自引率
0.00%
发文量
33
审稿时长
>12 weeks
期刊介绍: NeuroMolecular Medicine publishes cutting-edge original research articles and critical reviews on the molecular and biochemical basis of neurological disorders. Studies range from genetic analyses of human populations to animal and cell culture models of neurological disorders. Emerging findings concerning the identification of genetic aberrancies and their pathogenic mechanisms at the molecular and cellular levels will be included. Also covered are experimental analyses of molecular cascades involved in the development and adult plasticity of the nervous system, in neurological dysfunction, and in neuronal degeneration and repair. NeuroMolecular Medicine encompasses basic research in the fields of molecular genetics, signal transduction, plasticity, and cell death. The information published in NEMM will provide a window into the future of molecular medicine for the nervous system.
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