[Research progress in the effects of stress on microglial immune checkpoints].

Yue Cao, Junfeng Zhang
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Abstract

Microglia are the resident immune cells of the central nervous system (CNS). Microglia are usually in the surveillant or quiescent state which is tightly regulated by several mechanisms called microglial immune checkpoints. Microglial immune checkpoint mechanism consists of four dimensions: soluble restraining factors, cell-to-cell interactions, seclusion from the circulation, and transcriptional regulators. Stress may lead to a more potent activation state of microglia when a subsequent immune challenge arrives, which is known as the microglial priming. Stress can prime microglia by affecting microglial checkpoints.

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[应激对小胶质免疫检查点影响的研究进展]。
小胶质细胞是中枢神经系统(CNS)的常驻免疫细胞。小胶质细胞通常处于监视或静止状态,这种状态受到称为小胶质免疫检查点的几种机制的严格调节。小胶质细胞免疫检查点机制包括四个维度:可溶性抑制因子、细胞间相互作用、循环隔离和转录调节因子。当随后的免疫挑战到来时,压力可能导致小胶质细胞更有效的激活状态,这被称为小胶质细胞启动。压力可以通过影响小胶质细胞检查点来激活小胶质细胞。
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