Relationships between Inflammatory Biomarkers and Fatigue among Patients with Moderate and Severe COVID-19.

IF 2.6 Q3 IMMUNOLOGY International Journal of Inflammation Pub Date : 2023-01-01 DOI:10.1155/2023/7057458

Besher A Gharaibeh, Jehad Rababah, Obieda Haneyah

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Abstract

Background: Patients with moderate or severe COVID-19 infection suffer from varying levels of fatigue; however, there is a lack of understanding regarding the effect of inflammation on fatigue; and whether these relationships differ according to the severity of the infection.

Aim: To assess the relationships between selected inflammatory biomarkers and fatigue levels among hospitalized Jordanian patients with moderate or severe COVID-19 infection.

Methods: A quantitative cross-sectional design was used. A total of 352 participants were recruited for the study. Data regarding fatigue type and level were collected using the Chalder fatigue scale. Laboratory test results regarding several selected inflammatory biomarkers (e.g., ESR, CRP, IL-6, D-dimer, and others) were collected from patient records. The severity of the COVID-19 infection was determined using the criteria of the Ministry of Health in Jordan based on the results of O₂% (oxygen saturation).

Results: The mean scores of the total fatigue level significantly differed between the two levels of the severity of COVID-19 infection (moderate and severe levels) (t = -3.0, p < 0.05). Similar findings were observed with physiological fatigue (t = -3.50, p < 0.05), and no significant difference was observed in psychological fatigue. Out of the selected inflammatory markers, only neutrophil and lymphocyte count had a significant influence on total fatigue level.

Conclusion: The level and type of fatigue was affected by the severity of the disease. However, the disease process itself represented by the levels of the inflammatory markers showed little influence on fatigue. The implications such as continuous screening of fatigue, and monitoring of the levels of the inflammatory markers are important to assist in diagnosing and managing COVID-19 patients. Furthermore, the relationship between the inflammatory process and fatigue is complex and requires further exploration.

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中重度COVID-19患者炎症生物标志物与疲劳的关系

背景:中重度COVID-19感染患者存在不同程度的疲劳;然而，人们对炎症对疲劳的影响缺乏了解;以及这些关系是否根据感染的严重程度而有所不同。目的:评估约旦中重度COVID-19感染住院患者中选定炎症生物标志物与疲劳水平之间的关系。方法:采用定量横断面设计。这项研究共招募了352名参与者。使用Chalder疲劳量表收集疲劳类型和水平的数据。从患者记录中收集了几种选定的炎症生物标志物(如ESR、CRP、IL-6、d -二聚体等)的实验室检测结果。COVID-19感染的严重程度是根据约旦卫生部根据O2%(血氧饱和度)结果制定的标准确定的。结果:两种感染严重程度(中度和重度)患者总疲劳水平平均得分差异有统计学意义(t = -3.0, p < 0.05)。生理疲劳与心理疲劳的差异无统计学意义(t = -3.50, p < 0.05)。在选定的炎症标志物中，只有中性粒细胞和淋巴细胞计数对总疲劳水平有显著影响。结论:疲劳程度和类型受疾病严重程度的影响。然而，由炎症标志物水平所代表的疾病过程本身对疲劳的影响很小。持续筛查疲劳和监测炎症标志物水平等影响对于协助诊断和管理COVID-19患者非常重要。此外，炎症过程与疲劳之间的关系是复杂的，需要进一步探索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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