Age-related differences in white matter microstructure measured by advanced diffusion MRI in healthy older adults at risk for Alzheimer’s disease

IF 1.7 Q3 CLINICAL NEUROLOGY Aging brain Pub Date : 2022-01-01 DOI:10.1016/j.nbas.2022.100030
Alice Motovylyak , Nicholas M. Vogt , Nagesh Adluru , Yue Ma , Rui Wang , Jennifer M. Oh , Steven R. Kecskemeti , Andrew L. Alexander , Douglas C. Dean , Catherine L. Gallagher , Mark A. Sager , Bruce P. Hermann , Howard A. Rowley , Sterling C. Johnson , Sanjay Asthana , Barbara B. Bendlin , Ozioma C. Okonkwo
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引用次数: 6

Abstract

Neurite orientation dispersion and density imaging (NODDI) is an advanced diffusion imaging technique, which can detect more distinct microstructural features compared to conventional Diffusion Tensor Imaging (DTI). NODDI allows the signal to be divided into multiple water compartments and derive measures for orientation dispersion index (ODI), neurite density index (NDI) and volume fraction of isotropic diffusion compartment (FISO). This study aimed to investigate which diffusion metric—fractional anisotropy (FA), mean diffusivity (MD), NDI, ODI, or FISO—is most influenced by aging and reflects cognitive function in a population of healthy older adults at risk for Alzheimer’s disease (AD). Age was significantly associated with all but one diffusion parameters and regions of interest. NDI and MD in the cingulate region adjacent to the cingulate cortex showed a significant association with a composite measure of Executive Function and was proven to partially mediate the relationship between aging and Executive Function decline. These results suggest that both DTI and NODDI parameters are sensitive to age-related differences in white matter regions vulnerable to aging, particularly among older adults at risk for AD.

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在阿尔茨海默病风险的健康老年人中,高级扩散MRI测量的白质微结构的年龄相关差异
神经突定向弥散和密度成像(NODDI)是一种先进的扩散成像技术,与传统的扩散张量成像(DTI)相比,可以检测到更清晰的微结构特征。NODDI可以将信号划分为多个水区,并推导出取向弥散指数(ODI)、神经突密度指数(NDI)和各向同性扩散区体积分数(FISO)的测量方法。本研究旨在探讨哪一种扩散指标——分数各向异性(FA)、平均扩散率(MD)、NDI、ODI或fso——受年龄影响最大,并反映有阿尔茨海默病(AD)风险的健康老年人群体的认知功能。年龄与除一个扩散参数和感兴趣的区域外的所有扩散参数和区域显著相关。扣带皮层附近扣带区的NDI和MD与执行功能的综合测量有显著的关联,并被证明部分介导衰老和执行功能下降之间的关系。这些结果表明,DTI和NODDI参数对易衰老的白质区域的年龄相关差异很敏感,特别是在有AD风险的老年人中。
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Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
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