Changes in lipid lowering medication and lipid levels over time in patients with stable coronary artery disease.

IF 1.6 4区 医学 Q2 Medicine Acta Clinica Belgica Pub Date : 2023-04-01 DOI:10.1080/17843286.2022.2084948
Clara François, A M Willems, L Van Calster, E Germonpré, Johan De Sutter
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引用次数: 0

Abstract

Background/aim: To provide longitudinal data on the evolution of lipid levels and the intake of lipid-lowering therapies in patients with stable coronary artery disease.

Methods: Single-centre retrospective study with inclusion of 350 patients with a first coronary artery event in 2014 or earlier and outpatient cardiac clinic follow-up in 2015 and 2019. Lipid levels were collected within a time frame of 3 months of their visits.This retrospective study protocol (2020.086) was approved by the ethical committee and by the Data Privacy Officer of AZ Maria Middelares Ghent. For this type of study, formal consent is not required, following local law and regulations.

Results: Average LDL levels were 82 (±26) mg/dl in 2015 and 70 (±24) mg/dl in 2019 (p < 0.001). Most patients included were already on statin treatment before inclusion in the trial (94%), with a significant increase in high-intensity statin use (45% vs. 58%) after a 5-year follow-up. At the same time, we observed a significant increase in ezetimibe use (in combination with statin therapy or in monotherapy) (8% vs. 22%) during follow-up. LDL ≤70 mg/dl was 34% in 2015 and 53% in 2019. LDL ≤55 mg/dl was 13% in 2015 and 28% in 2019.

Conclusion: This study shows significant intensification of lipid-lowering therapy use during follow-up, and a significant lipid level lowering after 5-year follow-up, in an outpatient cardiac clinic follow-up. Further improvement in lipid control is still desirable, especially after the European Society of Cardiology recommend stricter lipid levels in the 2021 Prevention Guidelines.

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稳定冠状动脉疾病患者降脂药物和脂质水平随时间的变化
背景/目的:为稳定型冠状动脉疾病患者血脂水平的演变和降脂治疗的摄入提供纵向数据。方法:单中心回顾性研究,纳入350例2014年或更早发生首次冠状动脉事件的患者,并于2015年和2019年进行门诊心脏门诊随访。血脂水平是在3个月的时间框架内收集的。本回顾性研究方案(2020.086)经伦理委员会和AZ Maria Middelares Ghent数据隐私官批准。对于此类研究,根据当地法律法规,不需要正式同意。结果:2015年的平均LDL水平为82(±26)mg/dl, 2019年为70(±24)mg/dl (p)。结论:本研究显示,在随访期间,降脂治疗的使用显著加强,在5年的门诊心脏临床随访中,血脂水平显著降低。进一步改善脂质控制仍然是可取的,特别是在欧洲心脏病学会在2021年预防指南中建议更严格的脂质水平之后。
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来源期刊
Acta Clinica Belgica
Acta Clinica Belgica 医学-医学:内科
CiteScore
2.90
自引率
0.00%
发文量
44
审稿时长
6-12 weeks
期刊介绍: Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine primarily publishes papers on clinical medicine, clinical chemistry, pathology and molecular biology, provided they describe results which contribute to our understanding of clinical problems or describe new methods applicable to clinical investigation. Readership includes physicians, pathologists, pharmacists and physicians working in non-academic and academic hospitals, practicing internal medicine and its subspecialties.
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