Molecular Mechanisms of T Helper Cell Differentiation and Functional Specialization.

IF 4.3 4区 医学 Q2 IMMUNOLOGY Immune Network Pub Date : 2023-02-17 eCollection Date: 2023-02-01 DOI:10.4110/in.2023.23.e4
Gap Ryol Lee
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Abstract

Th cells, which orchestrate immune responses to various pathogens, differentiate from naïve CD4 T cells into several subsets that stimulate and regulate immune responses against various types of pathogens, as well as a variety of immune-related diseases. Decades of research have revealed that the fate decision processes are controlled by cytokines, cytokine receptor signaling, and master transcription factors that drive the differentiation programs. Since the Th1 and Th2 paradigm was proposed, many subsets have been added to the list. In this review, I will summarize these events, including the fate decision processes, subset functions, transcriptional regulation, metabolic regulation, and plasticity and heterogeneity. I will also introduce current topics of interest.

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T 辅助细胞分化和功能特化的分子机制
Th细胞能协调对各种病原体的免疫反应,它从幼稚的CD4 T细胞分化成多个亚群,刺激和调节对各种病原体以及各种免疫相关疾病的免疫反应。数十年的研究表明,命运决定过程受细胞因子、细胞因子受体信号转导和主转录因子的控制,它们驱动着分化程序。自 Th1 和 Th2 范式提出以来,又有许多亚群加入到这一列表中。在这篇综述中,我将总结这些事件,包括命运决定过程、亚群功能、转录调控、代谢调控以及可塑性和异质性。我还将介绍当前感兴趣的话题。
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来源期刊
Immune Network
Immune Network Immunology and Microbiology-Immunology
CiteScore
2.90
自引率
3.30%
发文量
36
期刊介绍: Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
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