A Preliminary Study on the Correlation Between Age and Endometrial Receptivity.

IF 1.8 4区 医学 Q3 PHARMACOLOGY & PHARMACY Pharmacogenomics & Personalized Medicine Pub Date : 2023-01-01 DOI:10.2147/PGPM.S406257
Song Guo, Di Zhang, Shan Zhao, Huan Zhang, Yijuan Sun, Li Yan
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Abstract

Background: It is well established that female fertility declines with age, primarily because of loss of ovarian function. However, few studies have clarified the relationship between increasing age and endometrial receptivity. Here, we aimed to study the impact of age on endometrial receptivity, meanwhile, we examined the expression of endometrial mesenchymal stem cell (eMSC) surface markers (CD146 and PDGF-Rβ), essential for endometrial development and re-growth, in different age groups.

Methods: Participants were enrolled in this study between October 2020 and July 2021. All 31 patients were divided into three age groups; early (30-39 years old, n=10), intermediate (40-49 years old, n=12) and advanced (≥50 years old, n=9). We assessed localization and expression of CD146 and PDGF-Rβ by immunofluorescence and further analyzed selected endometrial receptivity markers (Homeobox A10 HOXA10, leukemia inhibitory factor LIF and osteopontin) and steroid hormone receptors by immunohistochemistry.

Results: There were no significant differences in expression of HOXA10 and OPN (p>0.05) among the three groups. However, we found a significant difference in LIF expression between the early and advanced age groups, with higher expression noted in the latter group (p=0.02). Similarly, estrogen receptor (ER) and progesterone receptor (PR) expression were significantly increased (p=0.01 and p=0.01, respectively) in the advanced age group compared with the early age group. There were no significant difference in CD146 and PDGF-Rβ expression among the three groups (p>0.05).

Conclusion: These results suggest that the age of the patient does not influence their endometrial receptivity. So, this study serves to increase our understanding of the impact of age and eMSCs on endometrial receptivity and expands the etiology of age-related infertility.

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年龄与子宫内膜容受性相关性的初步研究。
背景:众所周知,女性生育能力随着年龄的增长而下降,主要是因为卵巢功能的丧失。然而,很少有研究阐明年龄增长与子宫内膜容受性之间的关系。在此,我们旨在研究年龄对子宫内膜容受性的影响,同时,我们检测了不同年龄组子宫内膜间充质干细胞(eMSC)表面标志物(CD146和PDGF-Rβ)的表达,这是子宫内膜发育和再生所必需的。方法:参与者在2020年10月至2021年7月期间入组。31例患者分为3个年龄组;早期(30-39岁,n=10)、中期(40-49岁,n=12)和晚期(≥50岁,n=9)。我们通过免疫荧光检测CD146和PDGF-Rβ的定位和表达,并进一步通过免疫组织化学分析选定的子宫内膜容受性标志物(Homeobox A10 HOXA10、白血病抑制因子LIF和骨桥蛋白)和类固醇激素受体。结果:三组患者HOXA10、OPN的表达差异无统计学意义(p>0.05)。然而,我们发现早期和晚期年龄组之间LIF表达有显著差异,后者表达较高(p=0.02)。老年组雌激素受体(ER)和孕激素受体(PR)的表达也明显高于早期组(p=0.01和p=0.01)。三组间CD146、PDGF-Rβ表达差异无统计学意义(p>0.05)。结论:这些结果提示患者的年龄不影响其子宫内膜容受性。因此,本研究有助于增加我们对年龄和eMSCs对子宫内膜容受性的影响的理解,并扩展年龄相关性不孕的病因学。
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来源期刊
Pharmacogenomics & Personalized Medicine
Pharmacogenomics & Personalized Medicine Biochemistry, Genetics and Molecular Biology-Molecular Medicine
CiteScore
3.30
自引率
5.30%
发文量
110
审稿时长
16 weeks
期刊介绍: Pharmacogenomics and Personalized Medicine is an international, peer-reviewed, open-access journal characterizing the influence of genotype on pharmacology leading to the development of personalized treatment programs and individualized drug selection for improved safety, efficacy and sustainability. In particular, emphasis will be given to: Genomic and proteomic profiling Genetics and drug metabolism Targeted drug identification and discovery Optimizing drug selection & dosage based on patient''s genetic profile Drug related morbidity & mortality intervention Advanced disease screening and targeted therapeutic intervention Genetic based vaccine development Patient satisfaction and preference Health economic evaluations Practical and organizational issues in the development and implementation of personalized medicine programs.
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