Physical activity moderates the association between executive function and functional connectivity in older adults

IF 1.7 Q3 CLINICAL NEUROLOGY Aging brain Pub Date : 2022-01-01 DOI:10.1016/j.nbas.2022.100036
Marissa A Gogniat, Talia L Robinson, Kharine R Jean, L Stephen Miller
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引用次数: 4

Abstract

Recent evidence suggests that physical activity may influence the functional connectivity of the aging brain. The purpose of this study was to examine the influence of physical activity on the association between executive function and functional connectivity of key brain networks and graph theory metrics in community-dwelling older adults. Participants were 47 older adults (M = 73 years; SD = 5.92) who participated in neuropsychological testing, physical activity measurements, and magnetic resonance imaging (MRI). Seed-to-voxel moderation analyses and graph theory analyses were conducted. Physical activity was significantly positively associated with default mode network functional connectivity (DMN FC; Posterior Cingulate Gyrus, p-FDR = 0.005; Frontal Pole (L), p-FDR = 0.005; Posterior Cingulate Gyrus, p-FDR = 0.006; Superior Frontal Gyrus (L), p-FDR = 0.016) and dorsal attention network functional connectivity (DAN FC; Inferior Frontal Gyrus Pars Opercularis (R), p-FDR = 0.044). The interaction between physical activity and executive function on the DMN FC and DAN FC was analyzed. The interaction between executive function and physical activity was significantly associated with DMN FC. When this significant interaction was probed, the association between physical activity and DMN FC differed between levels of high and low executive function such that the association was only significant at levels of high executive function. These results suggest that greater physical activity in later life is associated with greater DMN and DAN FC and provides evidence for the importance of physical activity in cognitively healthy older adults.

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体育活动调节老年人执行功能和功能连接之间的关联
最近的证据表明,体育活动可能会影响老化大脑的功能连接。本研究旨在探讨体力活动对社区居住老年人执行功能与关键脑网络功能连通性和图论指标之间关系的影响。参与者为47名老年人(M = 73 岁;SD = 5.92),他们参加了神经心理测试、身体活动测量和磁共振成像(MRI)。进行了种子到体素的调节分析和图论分析。体育活动与默认模式网络功能连通性(DMN FC)显著正相关;扣带后回,p-FDR = 0.005;额极(L), p-FDR = 0.005;扣带后回,p-FDR = 0.006;额上回(L), p-FDR = 0.016)和背侧注意网络功能连通性(DAN FC;额下回盖部(R), p-FDR = 0.044)。分析了运动与DMN和DAN FC执行功能的相互作用。执行功能和身体活动之间的相互作用与DMN FC显著相关。当这种显著的相互作用被探究时,体力活动和DMN FC之间的关联在高执行功能和低执行功能水平之间存在差异,因此这种关联仅在高执行功能水平上显着。这些结果表明,晚年更多的体育活动与更高的DMN和DAN FC有关,并为体育活动对认知健康的老年人的重要性提供了证据。
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Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
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