Effect of striatal dopamine on Pavlovian bias. A large [¹⁸F]-DOPA PET study.

IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES Behavioral neuroscience Pub Date : 2023-06-01 DOI:10.1037/bne0000547
Ping Chen, Dirk E M Geurts, Jessica I Määttä, Ruben van den Bosch, Lieke Hofmans, Danae Papadopetraki, Hanneke den Ouden, Roshan Cools
{"title":"Effect of striatal dopamine on Pavlovian bias. A large [¹⁸F]-DOPA PET study.","authors":"Ping Chen,&nbsp;Dirk E M Geurts,&nbsp;Jessica I Määttä,&nbsp;Ruben van den Bosch,&nbsp;Lieke Hofmans,&nbsp;Danae Papadopetraki,&nbsp;Hanneke den Ouden,&nbsp;Roshan Cools","doi":"10.1037/bne0000547","DOIUrl":null,"url":null,"abstract":"<p><p>Interaction between Pavlovian and instrumental control systems is key for adaptive motivated behavior, but also plays an important role in various neuropsychiatric disorders, including depression, addiction, and anxiety. Here, we employed the flouorodopa positron emission tomography ([¹⁸F]-DOPA PET) in healthy participants (<i>N</i> = 100) to assess whether dopamine synthesis capacity (K<sub>i</sub>), specifically in the ventral striatum, accounts for individual variation in Pavlovian-to-instrumental transfer (PIT). Surprisingly, this was not the case. Rather, the relationship of ventral striatal Ki with PIT depended on working memory (WM) capacity. Ventral striatal dopamine boosted the effects of Pavlovian cues on instrumental responding to a greater degree in participants with higher WM capacity. Caution is warranted to interpret this post hoc four-way interaction given the modest sample size. Nonetheless, these results chime with prior findings demonstrating that dopaminergic drugs boost Pavlovian biases to a greater degree in participants with greater WM capacity and highlight the importance of interactions between striatal dopamine and WM capacity. (PsycInfo Database Record (c) 2023 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"137 3","pages":"184-195"},"PeriodicalIF":1.6000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Behavioral neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1037/bne0000547","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
引用次数: 1

Abstract

Interaction between Pavlovian and instrumental control systems is key for adaptive motivated behavior, but also plays an important role in various neuropsychiatric disorders, including depression, addiction, and anxiety. Here, we employed the flouorodopa positron emission tomography ([¹⁸F]-DOPA PET) in healthy participants (N = 100) to assess whether dopamine synthesis capacity (Ki), specifically in the ventral striatum, accounts for individual variation in Pavlovian-to-instrumental transfer (PIT). Surprisingly, this was not the case. Rather, the relationship of ventral striatal Ki with PIT depended on working memory (WM) capacity. Ventral striatal dopamine boosted the effects of Pavlovian cues on instrumental responding to a greater degree in participants with higher WM capacity. Caution is warranted to interpret this post hoc four-way interaction given the modest sample size. Nonetheless, these results chime with prior findings demonstrating that dopaminergic drugs boost Pavlovian biases to a greater degree in participants with greater WM capacity and highlight the importance of interactions between striatal dopamine and WM capacity. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
纹状体多巴胺对巴甫洛夫偏向的影响。一项大型[¹⁸F]-多巴PET研究。
巴甫洛夫控制系统和工具控制系统之间的相互作用是适应性动机行为的关键,但在各种神经精神疾病中也起着重要作用,包括抑郁、成瘾和焦虑。在本研究中,我们使用了健康参与者(N = 100)的氟多巴正电子发射断层扫描([¹⁸F]-DOPA PET)来评估多巴胺合成能力(Ki),特别是腹侧纹状体,是否解释了巴甫洛夫-工具转移(PIT)的个体差异。令人惊讶的是,事实并非如此。相反,腹侧纹状体Ki与PIT的关系取决于工作记忆(WM)容量。腹侧纹状体多巴胺在更高WM能力的参与者中更大程度地增强了巴甫洛夫线索对工具性反应的影响。考虑到适度的样本量,解释这种事后的四向相互作用是有必要的。尽管如此,这些结果与先前的研究结果一致,表明多巴胺能药物在更大程度上促进了脑记忆能力更强的参与者的巴甫洛夫偏见,并强调了纹状体多巴胺和脑记忆能力之间相互作用的重要性。(PsycInfo数据库记录(c) 2023 APA,版权所有)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Behavioral neuroscience
Behavioral neuroscience 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
51
审稿时长
6-12 weeks
期刊介绍: Behavioral Neuroscience publishes original research articles as well as reviews in the broad field of the neural bases of behavior.
期刊最新文献
Methylphenidate differentially affects the social ultrasonic vocalizations of wild-type and prodromal Parkinsonian rats. Slight and hidden hearing loss in young rats is associated with impaired recognition memory and reduced myelination in the corpus callosum. Renewal of conditioned fear in male and female rats. N-tert-butoxycarbonyl-methylenedioxymethamphetamine, an methylenedioxymethamphetamine derivative, exhibits rewarding and reinforcing effects by increasing dopamine levels. Sex differences in behavior and glutamic acid decarboxylase in Long Evans rats after prolonged social isolation beginning in adolescence.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1