Drug interference with biochemical laboratory tests.

IF 3.8 3区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY Biochemia Medica Pub Date : 2023-06-15 DOI:10.11613/BM.2023.020601
Jasmina Katanić, Bojan Stanimirov, Vanesa Sekeruš, Maja Đanić, Nebojša Pavlović, Momir Mikov, Karmen Stankov
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Abstract

Clinical laboratory practice represents an essential part of clinical decision-making, as it influences 60-70% of medical decisions at all levels of health care. Results of biochemical laboratory tests (BLTs) have a key role in establishment of adequate diagnosis as well as in evaluation of treatment progress and outcome. The prevalence of drug-laboratory test interactions (DLTIs) is up to 43% of patients who had laboratory results influenced by drugs. Unrecognized DLTIs may lead to misinterpreted BLTs results, incorrect or delayed diagnosis, extra costs for unnecessary additional tests or inadequate therapy, as all may cause false clinical decisions. The significance of timely and adequate recognition of DLTIs is to prevent common clinical consequences such as incorrectly interpreted test results, delayed or non-treated condition due to erroneous diagnosis or unnecessary extra tests or therapy. Medical professionals should be educated that it is essential to obtain patient data about medications especially for the drugs used in the last 10 days before biological material collection. Our mini-review aims to provide a comprehensive overview of the current state in this important domain of medical biochemistry with detailed analysis of the effect of drugs on BLTs and to give detailed information to medical specialists.

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药物干扰生化实验室测试
临床实验室实践是临床决策的重要组成部分,因为它影响着各级卫生保健的60-70%的医疗决策。生化实验室试验(blt)的结果在建立充分的诊断以及评估治疗进展和结果方面具有关键作用。在实验室结果受药物影响的患者中,药物-实验室测试相互作用(dti)的发生率高达43%。未被识别的dlti可能导致对blt结果的误解、不正确或延迟的诊断、不必要的额外检查的额外费用或不充分的治疗,因为所有这些都可能导致错误的临床决策。及时和充分认识dti的意义在于防止常见的临床后果,如错误解释检查结果,由于错误诊断或不必要的额外检查或治疗而延误或未治疗的病症。应教育医疗专业人员,在收集生物材料之前,必须获得患者关于药物的数据,特别是最近10天内使用的药物的数据。我们的小型综述旨在全面概述医学生物化学这一重要领域的现状,详细分析药物对blt的影响,并向医学专家提供详细信息。
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来源期刊
Biochemia Medica
Biochemia Medica 医学-医学实验技术
CiteScore
5.50
自引率
3.00%
发文量
70
审稿时长
>12 weeks
期刊介绍: Biochemia Medica is the official peer-reviewed journal of the Croatian Society of Medical Biochemistry and Laboratory Medicine. Journal provides a wide coverage of research in all aspects of clinical chemistry and laboratory medicine. Following categories fit into the scope of the Journal: general clinical chemistry, haematology and haemostasis, molecular diagnostics and endocrinology. Development, validation and verification of analytical techniques and methods applicable to clinical chemistry and laboratory medicine are welcome as well as studies dealing with laboratory organization, automation and quality control. Journal publishes on a regular basis educative preanalytical case reports (Preanalytical mysteries), articles dealing with applied biostatistics (Lessons in biostatistics) and research integrity (Research integrity corner).
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