Circular RNAs as novel biomarkers in glomerular diseases.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Archives of Physiology and Biochemistry Pub Date : 2024-10-01 Epub Date: 2023-05-16 DOI:10.1080/13813455.2023.2212328

Seyyedeh Mina Hejazian, Yalda Rahbar Saadat, Seyed Mahdi Hosseiniyan Khatibi, Farahnoosh Farnood, Negin Farzamikia, Seyyed Sina Hejazian, Sepideh Batoumchi, Mohammadali M Shoja, Sepideh Zununi Vahed, Mohammadreza Ardalan

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Abstract

Circular RNAs (circRNAs) regulate gene expression and biological procedures by controlling target genes or downstream pathways by sponging their related miRNA (s). Three types of circRNAs have been identified; exonic circRNAs (ecircRNAs), intronic RNAs (ciRNAs), and exon-intron circRNAs (ElciRNAs). It is clarified that altered levels of circRNAs have dynamic pathological and physiological functions in kidney diseases. Evidence suggests that circRNAs can be considered novel diagnostic biomarkers and therapeutic targets for renal diseases. Glomerulonephritis (GN) is a general term used to refer to a wide range of glomerular diseases. GN is an important cause of chronic kidney diseases. Here, we review the biogenesis of circRNAs, and their molecular and physiological functions in the kidney. Moreover, the dysregulated expression of circRNAs and their biological functions are discussed in primary and secondary glomerulonephritis. Moreover, diagnostic and therapeutic values of circRNAs in distinguishing or treating different types of GN are highlighted.

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作为肾小球疾病新型生物标记物的环状 RNA。

环状 RNA（circRNA）通过海绵状的相关 miRNA 控制目标基因或下游通路，从而调节基因表达和生物过程。目前已发现三种类型的 circRNA：外显子 circRNA（ecircRNA）、内含子 RNA（ciRNA）和外显子内含子 circRNA（ElciRNA）。研究表明，circRNAs 水平的改变在肾脏疾病中具有动态的病理和生理功能。有证据表明，circRNAs 可被视为肾脏疾病的新型诊断生物标志物和治疗靶标。肾小球肾炎（GN）是一个泛指各种肾小球疾病的术语。肾小球肾炎是慢性肾脏疾病的一个重要病因。在此，我们回顾了 circRNAs 的生物生成及其在肾脏中的分子和生理功能。此外，还讨论了原发性和继发性肾小球肾炎中 circRNAs 的表达失调及其生物学功能。此外，还强调了 circRNAs 在区分或治疗不同类型肾小球肾炎方面的诊断和治疗价值。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.