Advances in Stem Cell Therapy for Intestinal Diseases: Mechanisms, Perspectives Regarding Clinical Applications, and Challenges.

IF 2.1 4区医学 Q4 CELL & TISSUE ENGINEERING Current stem cell research & therapy Pub Date : 2023-01-01 DOI:10.2174/1574888X17666220629094253

Weiwen Fan, Le Chang, Xinghua Pan, Xiangqing Zhu

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Abstract

Background: Intestinal disease is a common disease, which can cause serious digestion and absorption disorders, endanger the lives of patients and seriously affect the quality of life of people. Finding an effective treatment is a difficult problem at present, and stem cell therapy as a treatment has high application potential in intestinal-related diseases.

Purpose: This paper mainly summarizes the mechanism, research progress and future development trend of stem cells in the treatment of intestinal diseases in the past decade, hoping to provide a reference for future researchers in the research and application of stem cells and intestinal diseases.

Methods: Stem cells, inflammatory bowel diseases, Crohn's disease, radiation-induced intestinal injury, radiation enterocolitis, and extracellular vesicles were used as search terms. Relevant references in the past ten years were searched in CNKI journal full-text database, PubMed database, VIP network and Wanfang medical network, and 80 literature studies meeting the requirements were finally included for review.

Results: This paper summarizes the research and application of stem cells in intestinal diseases from 2012 to 2021, and expounds on the specific mechanism of stem cells in the treatment of intestinal diseases. It has been found that stem cells can treat intestinal injury or inflammation in different ways.

Conclusion: Future stem cells may also be used to reverse the natural aging of intestinal function, improve intestinal function, and strengthen gastrointestinal function.

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肠道疾病的干细胞治疗进展:机制、临床应用前景和挑战。

背景:肠道疾病是一种常见病，可引起严重的消化吸收障碍，危及患者生命，严重影响人们的生活质量。寻找有效的治疗方法是目前的难题，干细胞治疗作为一种治疗方法在肠道相关疾病中具有很高的应用潜力。目的:本文主要综述近十年来干细胞在肠道疾病治疗中的作用机制、研究进展及未来发展趋势，希望为未来研究者在干细胞与肠道疾病的研究与应用中提供参考。方法:以干细胞、炎症性肠病、克罗恩病、辐射性肠损伤、辐射性小肠结肠炎和细胞外囊泡为检索词。检索CNKI期刊全文数据库、PubMed数据库、VIP网、万方医学网近十年的相关文献，最终纳入80篇符合要求的文献研究进行综述。结果:本文总结了2012 - 2021年干细胞在肠道疾病中的研究与应用，阐述了干细胞治疗肠道疾病的具体机制。研究发现，干细胞可以以不同的方式治疗肠道损伤或炎症。结论:未来干细胞还可用于逆转肠道功能自然老化，改善肠道功能，增强胃肠功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current stem cell research & therapy CELL & TISSUE ENGINEERING-CELL BIOLOGY

CiteScore

4.20

自引率

3.70%

发文量

197

审稿时长

>12 weeks

期刊介绍： Current Stem Cell Research & Therapy publishes high quality frontier reviews, drug clinical trial studies and guest edited issues on all aspects of basic research on stem cells and their uses in clinical therapy. The journal is essential reading for all researchers and clinicians involved in stem cells research.