Dopamine Agonist-Induced Cerebrospinal Fluid Rhinorrhoea: A Case Report.

Abstract

Introduction: Prolactinomas are the most common pituitary adenomas. Medical therapy with dopamine agonists (DAs) is the mainstay of treatment and rarely requires surgical manipulation. Patients may rarely present with cerebrospinal fluid (CSF) rhinorrhoea after starting therapy with DA in case of massive or invasive prolactinomas.

Case description: We present a case of a 29-year-old lady with invasive prolactinoma who presented with CSF rhinorrhoea after a month of starting bromocriptine therapy with the development of meningitis and warranting early surgical repair.

Practical implications: Patients with macroprolactinoma should be closely monitored initially after starting on DA to avoid life-threatening complications.