Engineering approaches to investigate the roles of lymphatics vessels in rheumatoid arthritis

IF 1.9 4区 医学 Q3 HEMATOLOGY Microcirculation Pub Date : 2022-05-24 DOI:10.1111/micc.12769
Samantha E. Kraus, Esak Lee
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引用次数: 1

Abstract

Rheumatoid arthritis (RA) is one of the most common chronic inflammatory joint disorders. While our understanding of the autoimmune processes that lead to synovial degradation has improved, a majority of patients are still resistant to current treatments and require new therapeutics. An understudied and promising area for therapy involves the roles of lymphatic vessels (LVs) in RA progression, which has been observed to have a significant effect on mediating chronic inflammation. RA disease progression has been shown to correlate with dramatic changes in LV structure and interstitial fluid drainage, manifesting in the retention of distinct immune cell phenotypes within the synovium. Advances in dynamic imaging technologies have demonstrated that LVs in RA undergo an initial expansion phase of increased LVs and abnormal contractions followed by a collapsed phase of reduced lymphatic function and immune cell clearance in vivo. However, current animal models of RA fail to decouple biological and biophysical factors that might be responsible for this lymphatic dysfunction in RA, and a few attempted in vitro models of the synovium in RA have not yet included the contributions from the LVs. Various methods of replicating LVs in vitro have been developed to study lymphatic biology, but these have yet not been integrated into the RA context. This review discusses the roles of LVs in RA and the current engineering approaches to improve our understanding of lymphatic pathophysiology in RA.

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工程方法研究淋巴管在类风湿关节炎中的作用
类风湿性关节炎(RA)是最常见的慢性炎症性关节疾病之一。虽然我们对导致滑膜退化的自身免疫过程的了解有所改善,但大多数患者仍然对当前的治疗有抗药性,需要新的治疗方法。淋巴血管(lv)在类风湿关节炎进展中的作用是一个尚未得到充分研究和有前景的治疗领域,它在介导慢性炎症方面具有重要作用。RA疾病进展已被证明与左室结构和间质液引流的剧烈变化相关,表现为滑膜内不同免疫细胞表型的保留。动态成像技术的进步表明,RA中的lv经历了初始的扩张阶段,即lv增加和异常收缩,随后是体内淋巴功能和免疫细胞清除减少的崩溃阶段。然而,目前的RA动物模型未能分离可能导致RA淋巴功能障碍的生物和生物物理因素,并且一些尝试的RA滑膜体外模型尚未包括lv的贡献。在体外复制lv的各种方法已经发展到研究淋巴生物学,但这些还没有被整合到RA的背景下。本文综述了lv在类风湿关节炎中的作用以及目前的工程方法,以提高我们对类风湿关节炎淋巴病理生理的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Microcirculation
Microcirculation 医学-外周血管病
CiteScore
5.00
自引率
4.20%
发文量
43
审稿时长
6-12 weeks
期刊介绍: The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.
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