Recent Advancements in Prevention and Treatment of Osteoporosis with Traditional Chinese Medicine: A Long Way from Lab Bench to Bedside.

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Current molecular pharmacology Pub Date : 2023-01-01 DOI:10.2174/1874467215666220414145641

Jing Wang, Ji-Su Xue, Si-Min Huang

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引用次数: 2

Abstract

Osteoporosis is becoming more prevalent in the ageing society, however, its treatment is still a problem for both society and individuals. Traditional Chinese Medicine (TCM) has a long history in treating osteoporosis and is receiving increasing attention. Multiple formulas of TCM showed satisfactory effects in treating osteoporosis in both animal models and clinical patients. However, because TCM usually consists of multiple plant and/or animal products, it is difficult to clarify the mechanism of TCM according to the requirements of Western medicine regarding purity, efficacy, dosage, and safety. With increasing researchers have started to investigate the TCM using modern scientific tools such as bioinformatics and network pharmaceutics in osteoporosis and the addition of TCM in the latest version of International Statistical Classification of Diseases and Related Health Problems (ICD-11 version, 2019) by WHO, TCM is showing large potential in treating osteoporosis although there is still a long way. The review aimed to summarize recent advancements of TCM treating osteoporosis.

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中医药防治骨质疏松症的新进展:从实验室到临床的漫漫长路。

骨质疏松症在老龄化社会中越来越普遍，然而，其治疗仍然是一个社会和个人的问题。中医药治疗骨质疏松症的历史悠久，越来越受到人们的重视。多种中药方剂对骨质疏松症的动物模型和临床患者均有满意的疗效。然而，由于中药通常由多种植物和/或动物产品组成，很难根据西医对纯度、功效、剂量和安全性的要求来阐明中药的作用机制。随着越来越多的研究人员开始利用生物信息学、网络药剂学等现代科学工具对中医药在骨质疏松症中的应用进行研究，以及世界卫生组织将中医药纳入最新版《疾病与相关健康问题国际统计分类》(ICD-11版，2019)，中医药在骨质疏松症治疗方面显示出巨大的潜力，尽管还有很长的路要走。本文综述了中医药治疗骨质疏松症的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current molecular pharmacology Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

4.90

自引率

3.70%

发文量

112

期刊介绍： Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology. Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.