The platelet to lymphocyte ratio in heart failure: a comprehensive review.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2023-06-01 DOI:10.2478/rjim-2023-0006
Caterina Delcea, Cătălin Adrian Buzea, Ancuţa Elena Vîjan, Elisabeta Bădilă, Gheorghe-Andrei Dan
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Abstract

Introduction: At the crossroads of heart failure (HF) and systemic inflammation, platelets and lymphocytes are both influenced as well as actively participating in the bidirectional relationship. The platelet to lymphocyte ratio (PLR) could therefore be a marker of severity. This review aimed to assess the role of PLR in HF. Methods: We searched the PubMed (MEDLINE) database using the keywords "platelet", "thrombocyte", "lymphocyte", "heart failure", "cardiomyopathy", "implantable cardioverter defibrillator", "cardiac resynchronization therapy" and "heart transplant". Results: We identified 320 records. 21 studies were included in this review, with a total of 17,060 patients. PLR was associated with age, HF severity, and comorbidity burden. Most studies reported the predictive power for all-cause mortality. Higher PLR was associated with in-hospital and short-term mortality in univariable analysis, however, it was not consistently an independent predictor for this outcome. PLR > 272.9 associated an adjusted HR of 3.22 (95%CI 1.56 - 5.68, p<0.001) for 30-day fatality. During long-term follow-up from 6 months to 5 years, PLR was an independent predictor of mortality in most studies, with cut-off values ranging from > 150 to > 194.97 and adjusted HR from 1.47 (95%CI 1.06 - 2.03, p=0.019) to 5.65 (95%CI 2.47-12.96, p<0.001). PLR > 173.09 had an adjusted OR 2.89 (95%CI 1.17-7.09, p=0.021) for predicting response to cardiac resynchronization therapy. PLR was not associated with outcomes after cardiac transplant or implantable cardioverter-defibrillator. Conclusion: Increased PLR could be an auxiliary biomarker of severity and survival prognosis in HF patients.

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心力衰竭患者血小板与淋巴细胞比值的综合综述。
导读:在心力衰竭(HF)和全身性炎症的十字路口,血小板和淋巴细胞既受到影响,又积极参与双向关系。因此,血小板与淋巴细胞比率(PLR)可作为病情严重程度的标志。本综述旨在评估PLR在HF中的作用。方法:以“血小板”、“血小板”、“淋巴细胞”、“心力衰竭”、“心肌病”、“植入式心律转复除颤器”、“心脏再同步化治疗”、“心脏移植”等关键词检索PubMed (MEDLINE)数据库。结果:鉴定出320条记录。本综述纳入了21项研究,共计17060例患者。PLR与年龄、HF严重程度和合并症负担相关。大多数研究报告了全因死亡率的预测能力。在单变量分析中,较高的PLR与住院和短期死亡率相关,然而,它并不始终是该结果的独立预测因子。PLR > 272.9与预测心脏再同步化治疗反应相关的校正风险比为3.22 (95%CI 1.56 ~ 5.68, p 150 ~ > 194.97),校正风险比为1.47 (95%CI 1.06 ~ 2.03, p=0.019) ~ 5.65 (95%CI 2.47 ~ 12.96, p 173.09),校正风险比为2.89 (95%CI 1.17 ~ 7.09, p=0.021)。PLR与心脏移植或植入式心律转复除颤器后的预后无关。结论:PLR升高可作为心衰患者严重程度和生存预后的辅助生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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