Identification of Potential Indicators for Survival in Patients with Thyroid Cancer Based on Expression of FAM3 Members.

IF 1.5 4区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Critical Reviews in Eukaryotic Gene Expression Pub Date : 2023-01-01 DOI:10.1615/CritRevEukaryotGeneExpr.2022044417
Yuting Ma, Junfeng Shi, Yongping Liu, Weiming Cui, Ruiyan Pan, Hongyan Qiu, Fang Han, Ningning Hou, Xiaodong Sun
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Abstract

Thyroid cancer (THCA) is a common head and neck malignancy. The family with sequence similarity 3 (FAM3) is a cytokine-like gene family with four members, which is presumed to participate in the development of many cancer types. However, the expression patterns of FAM3s in THCA and their prognostic values, have not yet been established. We investigated differential expressions of FAM3 mRNA and protein in THCA, then validated the findings for FAM3B by immunohistochemistry. We also investigated survival data with respect to FAM3 expression patterns in patients with THCA. FAM3s information regarding their relationships with clinical pathological parameters were obtained and FAM3 mutations were assessed. KEGG and GO pathway regarding FAM3C were obtained using online databases. To investigate potential correlations between FAM3s and immune cell infiltration, we investigated the roles of FAM3s in immune cells of patients with THCA. The mRNA expression of FAM3C were significantly elevated in THCA tissues; high expression levels of FAM3C protein were also observed in THCA tissues. A significant association between the pathological stage and the expression of FAM3C was found in patients with THCA. Patients with THCA who had high mRNA expression levels of FAM3C exhibited significantly more favorable prognosis, compared with patients who had low mRNA expression levels of FAM3C. Overall, FAM3C may play vital roles in the pathogenesis and development of THCA, and these findings constitute novel insights for biomarkers of immunotherapeutic targeted agents and may aid in the identification of prognostic biomarkers for THCA.

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基于FAM3成员表达的甲状腺癌患者生存的潜在指标鉴定
甲状腺癌(THCA)是常见的头颈部恶性肿瘤。FAM3家族(family with sequence similarity 3, FAM3)是一个有4个成员的细胞因子样基因家族,被认为参与了许多癌症类型的发展。然而,fam3在THCA中的表达模式及其预后价值尚未确定。我们研究了FAM3 mRNA和蛋白在THCA中的差异表达,并通过免疫组织化学验证了FAM3B的结果。我们还研究了THCA患者中FAM3表达模式的生存数据。获得FAM3s与临床病理参数的关系,并评估FAM3突变。利用在线数据库获得FAM3C的KEGG和GO通路。为了探讨FAM3s与免疫细胞浸润之间的潜在相关性,我们研究了FAM3s在THCA患者免疫细胞中的作用。FAM3C mRNA在THCA组织中的表达显著升高;FAM3C蛋白在THCA组织中也有高表达。THCA患者的病理分期与FAM3C的表达有显著相关性。FAM3C mRNA表达水平高的THCA患者预后明显好于FAM3C mRNA表达水平低的THCA患者。总之,FAM3C可能在THCA的发病和发展中发挥重要作用,这些发现为免疫治疗靶向药物的生物标志物提供了新的见解,并可能有助于确定THCA的预后生物标志物。
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来源期刊
Critical Reviews in Eukaryotic Gene Expression
Critical Reviews in Eukaryotic Gene Expression 生物-生物工程与应用微生物
CiteScore
2.70
自引率
0.00%
发文量
67
审稿时长
1 months
期刊介绍: Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource. Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.
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