Comparison Between Pulsed and Continuous Accelerated Corneal Cross-Linking Protocols.

IF 1.8 Q3 OPHTHALMOLOGY Clinical ophthalmology Pub Date : 2023-01-01 DOI:10.2147/OPTH.S409178
Mohamed Omar Yousif, Rania Serag Elkitkat, Noha Abdelsadek Alaarag, Mouamen Moustafa Seleet, Ashraf Hassan Soliman
{"title":"Comparison Between Pulsed and Continuous Accelerated Corneal Cross-Linking Protocols.","authors":"Mohamed Omar Yousif,&nbsp;Rania Serag Elkitkat,&nbsp;Noha Abdelsadek Alaarag,&nbsp;Mouamen Moustafa Seleet,&nbsp;Ashraf Hassan Soliman","doi":"10.2147/OPTH.S409178","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To compare between two accelerated corneal cross-linking (A-CXL) protocols in the management of keratoconus (KC) as regard to the extent of corneal treatment.</p><p><strong>Methods: </strong>This retrospective, comparative study included patients having mild to moderate, progressive KC. The study population was divided into two groups; group 1 enrolled 103 eyes of 62 patients who received pulsed light A-CXL (pl-CXL) at a power of 30 mW/cm<sup>2</sup> with an irradiation time of 4 minutes, while group 2 comprised 87 eyes of 51 patients who received continuous light A-CXL (cl-CXL) at a power of 12 mW/cm<sup>2</sup> with an irradiation time of 10 minutes. Recordings of the central and peripheral demarcation line depths (DD), and the maximum (DDmax) and minimum (DDmin) DD, using anterior segment optical coherence tomography, were compared between the two studied groups one month after the treatment protocol. Treatment stability was also evaluated pre and postoperatively (one year following surgery) by comparing the refractive and keratometric outcomes in both groups.</p><p><strong>Results: </strong>The differences between the preoperative corneal thickness (minimum and central) and the epithelial thickness measurements between both groups were not statistically significant. Although group 1 had slightly larger central DD (223.4 ± 62.3 um), DDmax (240.4 ± 61.8 um), and DDmin (201 ± 54 um) than those of group 2 (221.8 ± 37 um, 229.1 ± 38.4 um, and 212 ± 37.2 um, respectively), the differences between both groups' measurements were not statistically significant. Also, the two groups showed statistically insignificant differences regarding the subjective refraction and the average and maximum keratometry pre and postoperatively, denoting visual, refractive, and keratometric stability in both groups.</p><p><strong>Conclusion: </strong>Longer duration cl-CXL seems to be as effective as pl-CXL regarding both postoperative stability and the extent of corneal tissue penetration by the ultraviolet treatment.</p>","PeriodicalId":10442,"journal":{"name":"Clinical ophthalmology","volume":"17 ","pages":"1407-1413"},"PeriodicalIF":1.8000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d1/0b/opth-17-1407.PMC10199693.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical ophthalmology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/OPTH.S409178","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: To compare between two accelerated corneal cross-linking (A-CXL) protocols in the management of keratoconus (KC) as regard to the extent of corneal treatment.

Methods: This retrospective, comparative study included patients having mild to moderate, progressive KC. The study population was divided into two groups; group 1 enrolled 103 eyes of 62 patients who received pulsed light A-CXL (pl-CXL) at a power of 30 mW/cm2 with an irradiation time of 4 minutes, while group 2 comprised 87 eyes of 51 patients who received continuous light A-CXL (cl-CXL) at a power of 12 mW/cm2 with an irradiation time of 10 minutes. Recordings of the central and peripheral demarcation line depths (DD), and the maximum (DDmax) and minimum (DDmin) DD, using anterior segment optical coherence tomography, were compared between the two studied groups one month after the treatment protocol. Treatment stability was also evaluated pre and postoperatively (one year following surgery) by comparing the refractive and keratometric outcomes in both groups.

Results: The differences between the preoperative corneal thickness (minimum and central) and the epithelial thickness measurements between both groups were not statistically significant. Although group 1 had slightly larger central DD (223.4 ± 62.3 um), DDmax (240.4 ± 61.8 um), and DDmin (201 ± 54 um) than those of group 2 (221.8 ± 37 um, 229.1 ± 38.4 um, and 212 ± 37.2 um, respectively), the differences between both groups' measurements were not statistically significant. Also, the two groups showed statistically insignificant differences regarding the subjective refraction and the average and maximum keratometry pre and postoperatively, denoting visual, refractive, and keratometric stability in both groups.

Conclusion: Longer duration cl-CXL seems to be as effective as pl-CXL regarding both postoperative stability and the extent of corneal tissue penetration by the ultraviolet treatment.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
脉冲和连续加速角膜交联方案的比较。
目的:比较两种加速角膜交联(A-CXL)治疗圆锥角膜(KC)的角膜治疗程度。方法:本研究为回顾性比较研究,纳入轻至中度进展性KC患者,研究人群分为两组;第1组纳入62例患者103眼,接受功率为30 mW/cm2的脉冲光a - cxl (pl-CXL),照射时间为4分钟;第2组纳入51例患者87眼,接受功率为12 mW/cm2的连续光a - cxl (cl-CXL),照射时间为10分钟。在治疗方案后1个月,比较两组患者的中央和外周分界线深度(DD)以及最大(DDmax)和最小(DDmin)的记录。通过比较两组的屈光和角膜测量结果,还评估了术前和术后(手术后一年)的治疗稳定性。结果:两组术前角膜厚度(最小和中心)和上皮厚度测量值差异无统计学意义。虽然1组的中心DD(223.4±62.3 um)、DDmax(240.4±61.8 um)和DDmin(201±54 um)略大于2组(分别为221.8±37 um、229.1±38.4 um和212±37.2 um),但两组间的测量差异无统计学意义。此外,两组在主观屈光、平均和最大角膜度数方面的术前和术后差异无统计学意义,表明两组的视力、屈光和角膜度数稳定性。结论:在紫外线治疗的术后稳定性和角膜组织穿透程度方面,持续时间较长的cl-CXL似乎与pl-CXL一样有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Clinical ophthalmology
Clinical ophthalmology OPHTHALMOLOGY-
CiteScore
3.50
自引率
9.10%
发文量
499
审稿时长
16 weeks
期刊最新文献
Optimal Duration of Monocular Occlusion to Eliminate Fusion Effect in Intermittent Exotropia Time Savings Using a Digital Workflow versus a Conventional for Intraocular Lens Implantation in a Corporate Chain Hospital Setting The Prevalence and Severity of Acquired Blepharoptosis in US Eye Care Clinic Patients and Their Receptivity to Treatment Fungal Keratitis: Diagnosis, Management, and Recent Advances Evaluation of Foveal Avascular Zone After Strabismic and Anisometropic Amblyopia Therapy in Saudi Children Using Optic Coherence Tomography Angiography: A Cohort Study
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1