Franco Lori, David B Weiner, Sandra A Calarota, Laurene M Kelly, Julianna Lisziewicz
{"title":"Cytokine-adjuvanted HIV-DNA vaccination strategies.","authors":"Franco Lori, David B Weiner, Sandra A Calarota, Laurene M Kelly, Julianna Lisziewicz","doi":"10.1007/s00281-006-0047-y","DOIUrl":null,"url":null,"abstract":"<p><p>This review highlights some of the most common cytokines currently being tested as adjuvants in HIV-1-DNA vaccine regimens. We discuss their use in both the prophylactic and therapeutic setting. Finally, we describe a novel dendritic cell-targeted vaccine candidate for HIV-1 treatment and prevention called DermaVir and explore the combination of the DermaVir technology with the cytokine adjuvants interleukin-7 and interleukin-15.</p>","PeriodicalId":74860,"journal":{"name":"Springer seminars in immunopathology","volume":"28 3","pages":"231-8"},"PeriodicalIF":0.0000,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00281-006-0047-y","citationCount":"31","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Springer seminars in immunopathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00281-006-0047-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 31
Abstract
This review highlights some of the most common cytokines currently being tested as adjuvants in HIV-1-DNA vaccine regimens. We discuss their use in both the prophylactic and therapeutic setting. Finally, we describe a novel dendritic cell-targeted vaccine candidate for HIV-1 treatment and prevention called DermaVir and explore the combination of the DermaVir technology with the cytokine adjuvants interleukin-7 and interleukin-15.