Cytokine-adjuvanted HIV-DNA vaccination strategies.

Franco Lori, David B Weiner, Sandra A Calarota, Laurene M Kelly, Julianna Lisziewicz
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引用次数: 31

Abstract

This review highlights some of the most common cytokines currently being tested as adjuvants in HIV-1-DNA vaccine regimens. We discuss their use in both the prophylactic and therapeutic setting. Finally, we describe a novel dendritic cell-targeted vaccine candidate for HIV-1 treatment and prevention called DermaVir and explore the combination of the DermaVir technology with the cytokine adjuvants interleukin-7 and interleukin-15.

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细胞因子佐剂的HIV-DNA疫苗接种策略
这篇综述强调了目前在HIV-1-DNA疫苗方案中作为佐剂进行测试的一些最常见的细胞因子。我们讨论了它们在预防和治疗两方面的应用。最后,我们描述了一种用于治疗和预防HIV-1的新型树突状细胞靶向疫苗候选物DermaVir,并探索了DermaVir技术与细胞因子佐剂白介素-7和白介素-15的结合。
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