The effect of early and long-term propranolol therapy on learning and memory in mice.

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES Behavioural Pharmacology Pub Date : 2023-06-01 DOI:10.1097/FBP.0000000000000725
Mehmet Fatih Orhan, Pelin Tanyeri, Mehmet Emin Büyükokuroğlu, Mustafa Büyükavci
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Abstract

Propranolol is the treatment of choice for infantile hemangioma. We investigated the effects of long-term propranolol use in early infancy on learning and memory later in life in mice. At three weeks of age, mice were randomly divided into six experimental groups. Groups 1 and 2 (controls) received only saline for 21 days. Groups 3 and 4 received propranolol (2.5 mg/kg) for 21 days. Groups 5 and 6 received propranolol (5 mg/kg) for 21 days. Groups 1, 3 and 5 were tested at the end of 21 days of treatment (week 6). However, groups 2, 4 and 6 received a 2-week break and then (week 8) exposed to tests. In the Morris water maze test, propranolol (2.5 and 5 mg/kg) dose-dependently increased the time spent in the target quadrant in mice at weeks 6 and 8. However, propranolol did not affect the swimming speed in both time periods. There were no significant effects of propranolol on the number of errors evaluated during the radial arm maze tests. In conclusion, long-term use of propranolol in early infancy did not disrupt the learning and memory of mice.

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心得安早期和长期治疗对小鼠学习记忆的影响。
心得安是治疗婴幼儿血管瘤的首选药物。我们研究了婴儿早期长期使用心得安对小鼠以后学习和记忆的影响。在三周龄时,将小鼠随机分为六个实验组。1组和2组(对照组)仅给予生理盐水治疗21 d。第3组和第4组给予心得安(2.5 mg/kg),连用21 d。第5组和第6组给予心得安(5 mg/kg),连用21 d。第1、3、5组在治疗第21天(第6周)结束时进行检测。第2、4、6组休息2周后(第8周)进行测试。在Morris水迷宫实验中,在第6周和第8周,普萘洛尔(2.5和5 mg/kg)剂量依赖性地增加了小鼠在目标象限的停留时间。然而,心得安在两个时间段内都没有影响游泳速度。普萘洛尔对桡臂迷宫试验中评估的错误数量没有显著影响。综上所述,在婴儿期长期使用心得安不会破坏小鼠的学习和记忆。
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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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