A comprehensive summary of disease variants implicated in metal allergy.

IF 6.4 2区 医学 Q1 ENVIRONMENTAL SCIENCES Journal of Toxicology and Environmental Health-Part B-Critical Reviews Pub Date : 2022-08-18 DOI:10.1080/10937404.2022.2104981
Ka Roach, Jr Roberts
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引用次数: 5

Abstract

Allergic disease represents one of the most prominent global public health crises of the 21st century. Although many different substances are known to produce hypersensitivity responses, metals constitute one of the major classes of allergens responsible for a disproportionately large segment of the total burden of disease associated with allergy. Some of the most prevalent forms of metal allergy - including allergic contact dermatitis - are well-recognized; however, to our knowledge, a comprehensive review of the many unique disease variants implicated in human cases of metal allergy is not available within the current scientific literature. Consequently, the main goal in composing this review was to (1) generate an up-to-date reference document containing this information to assist in the efforts of lab researchers, clinicians, regulatory toxicologists, industrial hygienists, and other scientists concerned with metal allergy and (2) identify knowledge gaps related to disease. Accordingly, an extensive review of the scientific literature was performed - from which, hundreds of publications describing cases of metal-specific allergic responses in human patients were identified, collected, and analyzed. The information obtained from these articles was then used to compile an exhaustive list of distinctive dermal/ocular, respiratory, gastrointestinal, and systemic hypersensitivity responses associated with metal allergy. Each of these disease variants is discussed briefly within this review, wherein specific metals implicated in each response type are identified, underlying immunological mechanisms are summarized, and major clinical presentations of each reaction are described.Abbreviations: ACD: allergic contact dermatitis, AHR: airway hyperreactivity, ASIA: autoimmune/ autoinflammatory syndrome induced by adjuvants, BAL: bronchoalveolar lavage, CBD: chronic beryllium disease, CTCL: cutaneous T-cell lymphoma, CTL: cytotoxic T-Lymphocyte, DRESS: drug reaction with eosinophilia and systemic symptoms, GERD: gastro-esophageal reflux disease, GI: gastrointestinal, GIP: giant cell interstitial pneumonia, GM-CSF: granulocyte macrophage-colony stimulating factor, HMLD: hard metal lung disease, HMW: high molecular weight, IBS: irritable bowel syndrome, Ig: immunoglobulin, IL: interleukin, LMW: low molecular weight, PAP: pulmonary alveolar proteinosis, PPE: personal protective equipment, PRR: pathogen recognition receptor, SLE: systemic lupus erythematosus, SNAS: systemic nickel allergy syndrome, Th: helper T-cell, UC: ulcerative colitis, UV: ultraviolet.

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与金属过敏有关的疾病变异的综合总结。
过敏性疾病是21世纪最突出的全球公共卫生危机之一。虽然已知有许多不同的物质会产生超敏反应,但金属是过敏原的主要类别之一,在与过敏相关的疾病总负担中占不成比例的很大一部分。一些最常见的金属过敏形式——包括过敏性接触性皮炎——是公认的;然而,据我们所知,在目前的科学文献中,还没有对人类金属过敏病例中涉及的许多独特疾病变异进行全面审查。因此,撰写这篇综述的主要目标是:(1)生成一份包含这些信息的最新参考文件,以协助实验室研究人员、临床医生、监管毒理学家、工业卫生学家和其他与金属过敏有关的科学家的工作;(2)确定与疾病相关的知识空白。因此,对科学文献进行了广泛的审查-从中确定,收集和分析了数百份描述人类患者金属特异性过敏反应病例的出版物。从这些文章中获得的信息随后被用于编制与金属过敏相关的独特皮肤/眼部、呼吸、胃肠道和全身超敏反应的详尽清单。本文简要讨论了每种疾病变异,其中确定了与每种反应类型相关的特定金属,总结了潜在的免疫机制,并描述了每种反应的主要临床表现。缩写:ACD:过敏性接触性皮炎,AHR:气道高反应性,ASIA:佐剂诱导的自身免疫/自身炎症综合征,BAL:支气管肺泡灌洗,CBD:慢性berylum病,CTCL:皮肤t细胞淋巴瘤,CTL:细胞毒性t淋巴细胞,DRESS:嗜酸性粒细胞增多和全身症状的药物反应,GERD:胃食管反流病,GI:胃肠道,GIP:巨细胞间质性肺炎,GM-CSF:粒细胞巨噬集落刺激因子,HMLD:硬金属肺病,HMW:高分子量,IBS:肠易激综合征,Ig:免疫球蛋白,IL:白细胞介素,LMW:低分子量,PAP:肺泡蛋白症,PPE:个人防护装备,PRR:病原体识别受体,SLE:系统性红斑狼疮,SNAS:系统性镍过敏综合征,Th:辅助性t细胞,UC:溃疡性结肠炎,UV:紫外线。
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来源期刊
CiteScore
13.80
自引率
6.90%
发文量
13
审稿时长
>24 weeks
期刊介绍: "Journal of Toxicology and Environmental Health: Part B - Critical Reviews" is an academic journal published by Taylor & Francis, focusing on the critical examination of research in the areas of environmental exposure and population health. With an ISSN identifier of 1093-7404, this journal has established itself as a significant source of scholarly content in the field of toxicology and environmental health. Since its inception, the journal has published over 424 articles that have garnered 35,097 citations, reflecting its impact and relevance in the scientific community. Known for its comprehensive reviews, the journal also goes by the names "Critical Reviews" and "Journal of Toxicology & Environmental Health, Part B, Critical Reviews." The journal's mission is to provide a platform for in-depth analysis and critical discussion of the latest findings in toxicology, environmental health, and related disciplines. By doing so, it contributes to the advancement of knowledge and understanding of the complex interactions between environmental factors and human health, aiding in the development of strategies to protect and improve public health.
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